Tepenné revaskularizace myokardu

Petr Němec

Cor Vasa 2007, 49(11):388-390  

Myocardial viability determined by positron emission tomography (PET) at 1-3 months after primary coronary intervention (PCI). A pilot study.

Petr Niederle, Otakar Bělohlávek, Pavel Formánek, Eva Mandysová

Cor Vasa 2007, 49(11):392-396 | DOI: 10.33678/cor.2007.140  

Aim:The objective of the pilot prospective study was to assess myocardial viability and perfusion in patients undergoing primary coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI = 22 patients) and non-ST-segment elevation myocardial infarction (NSTEMI = 5 patients), with a positive enzymatic response (troponin I) in all. Patients and methods:Twenty seven patients (22 men and 5 women; mean age 55.8 ± 5.5 yrs) were enrolled into the study. The PCI involved angioplasty (PTCA) with stenting (n = 17), primary stenting (n = 7), and single PTCA (n = 3). The presence of a viable myocardium...

Our experience with rehabilitation of patients undergoing surgery for heart valve disease

Svatopluk Nehyba, Václav Chaloupka, Roman Čerbák, Šárka Chaloupková

Cor Vasa 2007, 49(11):397-403 | DOI: 10.33678/cor.2007.141  

Aim of study:To assess the effect of an eight-week comprehensive rehabilitation program on basic circulatory parameters, left ventricular (LV) function, and functional capacity of patients after surgery for aortic and mitral valve disease. Patients:To date, a total of 22 patients (19 males and 3 females), with a mean age of 27-86 years (56 ± 16) have attended the rehabilitation program. Of this number, 16 had surgery for aortic stenosis, 4 for combined aortic valve disease, and 2 for mitral regurgitation. Overall, the surgical procedures included aortic valve replacement by a mechanical prosthesis in 15 patients, by...

Our initial experience with glycogen phosphorylase BB measurement in the diagnosis of acute coronary syndrome

David Stejskal, Bořek Lačňák, Eliška Sovová

Cor Vasa 2007, 49(11):405-407 | DOI: 10.33678/cor.2007.142  

Background:The commonly used laboratory markers of coronary involvement in subjects with acute coronary syndrome (ACS) are not myocardial ischemia-specific and show late irreversible involvement of the myocardium. A laboratory test has been searched for in order to distinguish individuals with myocardial ischemia and typical CAD symptoms from CAD-free individuals. Since 1989, several papers have appeared on the measurement of glycogen phosphorylase BB (GPBB) with in-house EIA methods describing unique diagnostic sensitivity and specificity of such a test for the assessment of myocardial necrosis and ischemia. Recently, the FDA approved this...

The new renin inhibitor aliskiren. The new drug blocking renin-angiotensin system. Will it meet the expectations?

Jiří Widimský

Cor Vasa 2007, 49(11):408-414 | DOI: 10.33678/cor.2007.143  

Aliskiren is the first oral renin inhibitor. In healthy individuals, single and multiple doses of aliskiren result in peak plasma levels within 3-6 hours and the mean biological half-life after multiple doses is 40.7 ± 10.7 hours. It is just this long half-life which makes it possible to administer the drug once daily and ensures good blood pressure control even in the morning. It is eliminated mainly unchanged in feces. Only a small proportion (12%) of aliskiren is excreted during first-pass liver metabolism in the liver, with less than 10% of aliskiren excreted via the kidneys. Hence, no dose adjustments are necessary in patients with impaired...

The long QT syndrome

Tomáš Novotný

Cor Vasa 2007, 49(11):416-425 | DOI: 10.33678/cor.2007.144  

The long QT syndrome is characterized by QT interval prolongation and increased risk of malignant arrhythmias, which can cause syncope or even sudden death. A typical feature is absence of structural cardiac disease. The article summarizes the most recent information on the syndrome "from cell to bedside": pathophysiology at molecular and cellular levels, clinical diagnosis and the current recommended therapeutic approaches. The acquired long QT syndrome and other hereditary arrhythmic syndromes are also briefly mentioned. In conclusion, the contribution of long QT syndrome research to the issue of sudden cardiac death in the general population is...

Inflammatory cardiomyopathy secondary to borrelia infection, without a systemic serologic response

Petr Kuchynka, Tomáš Paleček, Stanislav Šimek, Dagmar Hulínská, Sudheera Magage, Gabriela Dostálová, Štěpán Havránek, Aleš Linhart

Cor Vasa 2007, 49(11):426-430 | DOI: 10.33678/cor.2007.145  

Lyme carditis is the term used for cardiac involvement caused by infection by the spirochete Borrelia burgdorferi. The disease manifestations include mostly arrhythmias, with pericarditis or myocardial dysfunction being less common. The authors describe a case of Lyme cardiomyopathy with severe left ventricular systolic dysfunction. The final diagnosis was based solely on endomyocardial biopsy as the serological examination did not reveal any presence of specific antibodies against Borrelia. Subsequent antibiotic therapy with cephalosporins led to complete normalization of left ventricular systolic function. This case underlines the significance of...

Infectious endocarditis of the mitral valve following injury by a pet

Blanka Dokoupilová

Cor Vasa 2007, 49(11):431-433 | DOI: 10.33678/cor.2007.146  

Infectious endocarditis (IE) is a serious intracardiac infection, deadly in 100% of cases in the preantibiotic era. The introduction of penicillin and streptomycin into the therapeutic protocols was followed by a steep decrease in IE-related mortality to levels below 20%. Today, despite the advances in the diagnosis and treatment, IE continues to be a disease with an uncertain prognosis and total mortality in the range of 20-30%. In her case report, the author presents an unusual cause of IE, highlighting the need for multiple clinical examinations of at-risk individuals in a septic state.

A patient with a borderline coronary angiographic finding on the proximal LAD. Practical application of intravascular ultrasound to specify the relevance of stenosis and to identify the optimal therapeutic procedure

Vladimír Janovský, Jaroslav Januška, Marian Branny, Piotr Branny

Cor Vasa 2007, 49(11):435-437 | DOI: 10.33678/cor.2007.147  

We report the case of a patient with atypical chest pain referred for surgery based on the finding of intravascular ultrasound.

Kombinovaná katetrizační intervence na kmeni levé věnčité tepny a levé vnitřní karotické tepně

Josef Veselka, Daniela Černá, Peter Blaško

Cor Vasa 2007, 49(11):391 | DOI: 10.33678/cor.2007.139  

Zamyšlení nad postgraduální vědeckou výchovou lékařů

Cor Vasa 2007, 49(11):K304  

Zápis ze schůze výboru ČKS, konané dne 12. září 2007 v Brně

Cor Vasa 2007, 49(11):K305  

Zápis ze schůze výboru pracovní skupiny Srdeční selhání, konané 21. 9. 2007 v Olomouci

Cor Vasa 2007, 49(11):K306  

Domácí akce

Cor Vasa 2007, 49(11):K308-310