Cor et Vasa, 2004 (vol. 45), issue 7
Abstracts
ICD lead-related complications. Mid-term follow-up of 172 patients with nonthoracotomy implantation
Miroslav Novák, Pavel Kamarýt, Ivo Dvořák Jr, Pavel Mach, Tomáš Vykypěl, Jolana Müllerová
Cor Vasa 2004, 45(7):311-318
Aim:To establish the incidence of ICD lead-related complications, the time of their appearance, and to propose methods for their management. Methods:A group of 172 consecutive patients (mean age 59.6 ± 13.2 years, 140 males) with ICDs implanted between May 22, 1994 and July 31, 2003, were assessed. All the leads were transvenous leads; ventricular leads had active fixation in 51 cases, and atrial leads in 39. All (133 single-chamber and 39 dual-chamber) generators were implanted in the pectoral region. The patients were followed till September 30, 2003. Results:The total time of following the ICD leads...
Change in the fate of middle-aged men with acute myocardial infarction
Vladimír Staněk, Marie Gebauerová, Jan Horák, Petr Frídl, Růžena Jandová, Jiří Kettner, Jan Šochman, Jana Vrbská, Martin Wiendl, Jaroslav Ulman, Michael Želízko
Cor Vasa 2004, 45(7):319-325
Aim:The aim of our retrospective study was to evaluate the prognosis of males admitted to a coronary care unit with ST-segment elevation acute myocardial infarction in three periods characterized by different treatment strategies. Patients and method:The analysis was carried out in three series of male patients below 65 years of age. The first group of 362 men was hospitalized over the 1973-1977 period when no reperfusion therapy was available. The second group of 372 males was hospitalized over the 1991-1995 period when the general practice was thrombolytic therapy with streptokinase in all patients presenting within 6 hours,...
Pulmonary hypertension in aortic stenosis
Roman Čerbák, Helena Bedáňová, Leona Bočková, Sylva Kovalová, Josef Nečas, František Štětka, Jaroslav Vespalec
Cor Vasa 2004, 45(7):326-330
Aim of study:In some cases of advanced stages, aortic stenosis is associated with pulmonary hypertension. Our study was designed to determine its incidence, causes and implications for the patient's fate. Patients and method:100 consecutive patients with simple aortic stenosis, free of associated valve disease and coronary artery disease, referred for surgery for aortic stenosis at the Brno-based Center of Cardiovascular and Transplant Surgery, were examined using invasive and non-invasive techniques to determine the presence of pulmonary hypertension, left ventricular systolic and diastolic dysfunction, and left atrial size. Results:Pulmonary...
Oscilloscopic analysis of the defibrillation discharge for detecting implanted defibrillation lead integrity defects in experiment
Jan Bytešník, Vlastimil Vančura, Marie Kocinová, Věra Lánská, Petr Volík, Libert Malina
Cor Vasa 2004, 45(7):331-337
Aim of study:To assess the contribution of oscilloscopic recordings of the defibrillation discharge to detecting an implanted defibrillation lead defect in an experimental model, and to compare any differences in the course of test discharges with an energy of 1 J and 30 J. Material and method:Nine minipigs had endocardial SPS 75 UP/BP (Biotronik, Berlin, Germany) or Kainox RV 75 (Biotronik, Berlin, Germany) leads implanted transvenously into the apical region of the right ventricle with a Phylax 06 (Biotronik, Berlin, Germany) cardioverter-defibrillator (ICD) placed subcutaneously in the left pectoral region. Discharges of...
A follow-up of myocardial and pulmonary 123I MIBG accumulation. A contribution to study of graft denervation and sympathetic hyperactivation following heart transplantation
Ivan Málek, Marie Buncová, Miroslav Kocík, Bronislav Janek, Jan Pirk
Cor Vasa 2004, 45(7):339-342
A total of 34 patients following orthotopic heart transplantation were examined using 123I metaiodobenzyl guanidine (MIBG) scintigraphy. We found low rates of myocardial MIBG accumulation suggesting persistent sympathetic graft denervation. Pulmonary MIBG accumulation was increased, presumably due to sympathetic hyperactivation and pulmonary endothelial dysfunction. No association was demonstrated between scintigraphic findings and coronary graft lesions.
Apoptosis of peripheral T-lymphocytes during immunosuppression with Neoral or Tacrolimus, and during rejection episodes and their treatment in heart transplant recipients
Jan Hökl, Jan Černý, Petr Němec, Pavel Studeník, Helena Bedáňová, Alžběta Sirotková
Cor Vasa 2004, 45(7):343-345
Neoral and Tacrolimus were used as the major immunosuppressive drugs in 18 and 12 adult heart transplant recipients, respectively, included into this study. At 1 month after transplantation, acute rejection episodes were assessed by endomyocardial biopsy and those with grades 3 IB were treated with methylprednisolone or, when steroid-resistant, with ATG or OKT3. Spontaneous in vivo apoptosis of peripheral T-lymphocytes was detected by ELISA using assessment of DNA fragments. In stable patients, there was no significant difference in T-cell apoptosis between Neoral- and Tacrolimus-treated recipients. In patients treated for rejection episodes,...
Use of recombinant activated factor VII in cardiac surgery
Tomáš Vaněk, Jakub Hrabák, Martin Jareš, Zbyněk Straka, Petr Brůček, Jan Votava, Martin Zeman
Cor Vasa 2004, 45(7):346-348
The authors present their experience with the administration of supranormal-therapeutic doses (90 µg/kg) of recombinant activated factor VII in seven cardiac surgery patients. Recombinant activated factor VII was used postoperatively in the presence of intractable bleeding, 5 patients underwent postoperative revision before administration. Use of recombinant activated factor VII was followed by a significant reduction in blood losses (p < 0.05) associated with a shortening of INR and aPTT in laboratory tests. No patient was re-operated. The authors consider the administration of recombinant activated factor VII a most effective technique for...