Cévní postižení u pacientů s akromegalií

Cor Vasa 2002, 43(7-8):332-335

Vascular lesions in patients with acromegaly

Michal Kršek^*, Martin Prázný, Josef Marek, Jana Ježková, Václav Hána, Vladimír Weiss, Jan Škrha: III. interní klinika, Všeobecná fakultní nemocnice a 1. lékařská fakulta Univerzity Karlovy, Praha, Česká republika

Introduction:
Acromegaly is a disorder associated with increased cardiovascular morbidity and mortality rates. The aim of our study was to compare parameters of vascular function and morphology and establish their relationship to some biochemical variables.

Methods:
Twenty-two patients with hormonally active acromegaly and fifteen healthy controls were included in the study. The examination was performed in the morning after an overnight fast. The participants underwent clinical examination, measurement of IMT and laser-Doppler examination of microcirculation; blood samples were taken for laboratory analysis.

Results:
We confirmed the typical laboratory characteristics of acromegaly. We found significantly higher IMT (p < 0.05) in the group of acromegalic patients and impaired reactivity of microcirculation in this group of patients when postocclusive reactive hyperemia was decreased (PORH_max., p < 0.01) and the reaction was slower (PORH_max./t, p < 0.05). Similarly, the response after heating was impaired (TH_max., p < 0.05) and was slower (TH_max./t, p < 0.01) in the acromegalic patients. We did not find a clear-cut dependence between the vascular parameters and laboratory variables within the separate groups of patients.

Conclusion:
It can be concluded that patients with hormonally active acromegaly have significantly increased IMT as a marker of atherosclerotic damage to macrocirculation; the reactivity of microcirculation is impaired in this group as well. The etiology of vascular damage is probably multifactorial.