Co nám říkají klinické studie s negativním a neutrálním závěrem?

Jindfiich Špinar

Cor Vasa 2006, 48(5):168 | DOI: 10.33678/cor.2006.053  

Contrast exercise echocardiography in asymptomatic severe chronic aortic regurgitation.

Tomáš Marek, Petr Frídl, Petr Lupínek, Věra Lánská, Josef Kautzner

Cor Vasa 2006, 48(5):173-178 | DOI: 10.33678/cor.2006.055  

Background:Prediction of resting systolic dysfunction or progression of symptoms during a follow-up period of 18 months in asymptomatic men with chronic severe aortic regurgitation and left ventricular dilatation meeting the criteria for conservative treatment. Methods:49 men with asymptomatic chronic severe aortic regurgitation without cardiac or extracardiac diseases underwent contrast exercise echocardiography. Left ventricular parameters were measured by echocardiography at rest and during exercise along with assessment of exercise tolerance data. The information was used to predict development of symptoms and/or systolic...

Predicting left ventricular filling pressure by tissue Doppler echocardiography in inten-sive care.

Martin Hutyra, Tomáš Skála, Jiří Ostřanský, Dan Marek, Vladimíra Baslerová, Hana Grofková

Cor Vasa 2006, 48(5):180-185 | DOI: 10.33678/cor.2006.056  

Background:Based on published results of meta-analyses of large studies, hemodynamic monitoring using pulmonary artery catheters is not associated with improved prognosis of critically ill patients treated this way at resuscitation departments and intensive care units (ICU). Moreover, this examination is invasive and may be associated with some specific complications. This method is therefore recently being abandoned and there has been an effort to develop some other semi-invasive and non-invasive techniques of hemodynamic monitoring of critically ill patients. Aim:The aim of this study was to compare the examined echocardiographic...

Cellular therapy of coronary heart disease: a summary of state of the art, limitations and prospects. Part One. Introduction, techniques of myocardial cell transplantation, skeletal myoblasts.

Martin Pěnička, Petr Widimský, Tomasz Siminiak, Otto Lang, Karol Čurila, Kateřina Hesová

Cor Vasa 2006, 48(5):186-190 | DOI: 10.33678/cor.2006.057  

The review article examines the state of the art in cellular therapy of coronary heart disease and options of myocardial regeneration. The article summarizes data from experimental and pilot clinical studies, discusses in detail the limitations of cellular therapy, and provides an outline of future developments. The paper is divided into two parts. Part one provides background information and addresses the issue of cell transplantation into the myocardium and skeletal myoblasts. Part two covers the issue of stem cells and prospects of cellular therapy.

Virtual histology a novel method in interventional cardiology.

Tomáš Kovárník, Jan Horák, Ondřej Dostál, Michael Aschermann, Aleš Linhart

Cor Vasa 2006, 48(5):192-196 | DOI: 10.33678/cor.2006.058  

This review describes a new diagnostic method called virtual histology. The basic principles, indications, limitations and description of the technique are discussed. The authors present their own experience with virtual histology.

A female patient with critical peripheral artery disease in the presence of Buerger s disease after 45 years

Jiří Spáčil, Jaroslava Svobodová, Jiří Král

Cor Vasa 2006, 48(5):198-201 | DOI: 10.33678/cor.2006.059  

This is the case report of a woman receiving treatment from 1960 when she was 32 years old for inflammatory disease manifesting itself with inflammatory infiltrates on the limbs and occlusion of all crural arteries with critical peripheral artery disease (PAD). Treatment was capable of stabilizing the patient s condition so she developed no gangrene and required no amputation. Once she stopped smoking, which the patient originally denied, after myocardial infarction in 1994, the peripheral artery functional status improved considerably. The patient reported no claudications, distal perimolar pressure values were only slightly decreased. Arteriography...

"Double" ST-elevation acute myocardial infarction evolving in a patient transferred for primary PCI over a distance of 180 km

Petr Widimský, Radovan Jirmář, Zuzana Moťovská

Cor Vasa 2006, 48(5):172 | DOI: 10.33678/cor.2006.054  

CHARISMA. The Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance trial

Jaromír Hradec, Jindřich Špinar

Cor Vasa 2006, 48(5):202-206  

In the CHARISMA trial, the effect of 75 mg clopidogrel added to acetylsalicylic acid was evaluated in 15,603 patients with documented cardiovascular disease of atherosclerotic origin or at high risk of cardiovascular disease. The rates of the primary combined end point of efficacy-myocardial infarction, stroke or cardiovascular death-were 6.8% in patients treated with clopidogrel and 7.3% in patients on placebo (relative risk = 0.93; p = 0.22). While addition of clopidogrel to acetylsalicylic acid was not effective in patients in primary prevention (relative risk = 1.20; p = 0.20), the rate of the primary efficacy end point decreased significantly...

Zamyšlení

Cor Vasa 2006, 48(5):K103  

Zápis ze schůze výboru ČKS, konané dne 28. března 2006 v Praze

Cor Vasa 2006, 48(5):K103  

Kalendář odborných akcí

Cor Vasa 2006, 48(5):K106  

Úskalí při interpretaci plazmatické koncentrace natriuretického peptidu typu B

Radka Hazuková, Miloslav Pleskot

Cor Vasa 2006, 48(5):207-208 | DOI: 10.33678/cor.2006.061  

Komentář k diskusnímu příspěvku "Úskalí při interpretaci plazmatické koncentrace natriuretického peptidu typu B

Peter Jakubík, Tomáš Janota, Jaromír Hradec

Cor Vasa 2006, 48(5):210 | DOI: 10.33678/cor.2006.062