Časný diagnostický test testikulárních nádorů

Cor Vasa 2005, 46(3)

Effect of hypertension on 30-day outcomes of patients with acute myocardial infarction treated by thrombolysis or primary PCI. Analysis of PRAGUE-2 trial patients

Petr Widimský, Dana Bílková, David Voráč, Ladislav Groch, Tomáš Buděšínský, Michael Aschermann, Michael Želízko

Cor Vasa 2005, 46(3)

The effect of hypertension on the risk of stroke has been shown by many trials. The effect of hypertension on the risk of myocardial infarction is less clear. The aim of this study was to compare the 30-day outcome of patients with hypertension vs. normotensive subjects among patients with acute ST elevation myocardial infarction, randomized in the PRAGUE-2 trial. Methods:The PRAGUE-2 trial randomized, between 1999 and 2002, a total of 850 patients with acute ST-elevation myocardial infarction into two groups: streptokinase infusion in the nearest hospital (TL, N = 421) vs. immediate transport for primary percutaneous coronary intervention...

Differences in the risk profile and treatment of patients with stable angina in the Czech and Slovak Republics.

Jaromír Hradec, Viliam Bada, Václav Chaloupka, Martina Sachová

Cor Vasa 2005, 46(3)

Introduction:In 2001, a project called the "ATP Survey" (Angina Treatment Patterns) was carried out in seven European countries, Russia and China in an effort to obtain demographic data on patients with stable angina, to characterize current techniques of diagnosis and risk stratification, and to define current therapeutic standards. Results of the survey as obtained in the Czech Republic (CR) were published in Cor et Vasa. This paper shows the differences in the risk profiles of patients and therapeutic standards between the CR and the Slovak Republic (SR). Method:A total of 1,348 patients with stable angina took part in...

Management of post-infarction ventricular tachycardia by targeted surgical ablation using intraoperative mapping in sinus rhythm.

Jan Bytešník, Jan Pirk, Petr Peichl, Vlastimil Vančura, Josef Kautzner, Kateřina Lefflerová, Robert Čihák, Renata Krausová, Vladimír Vinduška, Zdeněk Hýža, Jindřich Stupka

Cor Vasa 2005, 46(3)

Aim:The aim of the study was to assess our own results in targeted surgical ablation of a potential arrhythmogenic substrate localized by intraoperative mapping in sinus rhythm in patients with sustained ventricular tachyarrhythmia (s-VTA) after myocardial infarction (MI). Method:A total of 77 consecutive patients (68 men, 9 women) with a mean age of 62.4 ± 8.5 years and left ventricular ejection fraction of 31.3 ± 8.8% developing, within one month or longer after a transmural MI, monomorphic or polymorphic sustained ventricular tachycardia (s-VT) and with inducible s-VTA by programmed ventricular pacing were...

Pulmonary arterial hypertension-new concepts of the genetics of the disease.

Michael Aschermann, Pavel Jansa, Marcela Škvařilová

Cor Vasa 2005, 46(3)

Pulmonary arterial hypertension (PAH) has multifactorial pathophysiology with endothelial dysfunction, vasoconstriction, pulmonary vessel wall remodeling and plexiform lesions contributing to increased pulmonary vascular resistance. Recent studies have shown the importance of several mediators in PAH pathophysiology, including prostacyclin, nitric oxide, serotonin, endothelin-1, several cytokines, chemokines, as well as members of the transforming growth factor-$ family (TGF-$). Mutations in two receptors of TGF-$ have been shown to be present in most of the cases of familial PAH, namely bone morphogenetic receptor type-2 (BMPR2) and activin-like kinase-1...

Metabolic aspects of hypertension control: are all antihypertensive agents equal?

Jiří Widimský jr.

Cor Vasa 2005, 46(3)

This brief overview discusses the potential differences in the metabolic action of different classes of antihypertensive agents in relation to the development of diabetes mellitus. A meta-analysis of large studies of antihypertensive therapy has shown renin-angiotensin system inhibitors are associated with the lowest risk of developing new-onset diabetes mellitus. New-onset diabetes mellitus may significantly raise the cardiovascular risk in the long run.

European System for Cardiac Operative Risk Evaluation (EuroSCORE): a promising mortality predictive risk stratification tool?

Milka Klinčeva, Petr Widimský

Cor Vasa 2005, 46(3)

The European System of Cardiac Operative Risk Evaluation (EuroSCORE) was published in 1999 and is used for patients undergoing cardiac surgery.Since then, its validity has been assessed by different cardiac centers in Europe, North America and Japan and has been accepted as the most accurate predictive tool in cardiac mortality after bypass surgery, combined CABG and valve surgery as well as thoracic aortic surgery.Results from studies show that additive EuroSCORE overestimates the mortality at lower EuroSCOREs (EuroSCORE Ł 6) and underestimates mortality at high EuroSCOREs (EuroSCORE ł 10). This can lead to serious mistakes in choosing patients...

Catheter-based myocardial revascularization-where are the current limits?

Michael Želízko, Bronislav Janek, Marek Hrnčárek, Vladimír Pořízka, Vladimír Karmazín, Jiří Kettner

Cor Vasa 2005, 46(3)

The aim of the paper is to draw attention to new options in catheter-based management of coronary heart disease. The advent of new technology and products expands the "conventional" indications for PCI to include more complex lesions. Management of left coronary artery lesions, bifurcation lesions, chronic coronary artery occlusion (formerly preferred indications for surgical myocardial revascularization) is gradually becoming routine procedures in interventional cardiology. The availability of drug-eluting stents will increase the number of patients with multi-vessel coronary lesions indicated for PCI. Acute coronary syndromes are the domain of interventional...