Cor Vasa 2019, 61(6):562-566 | DOI: 10.33678/cor.2019.048

Association of endothelin-1 with oxidative stress and inflammatory response in pre-hypertensives

Niranjan Gopala, Nachimuthu Maithilikarpagaselvib, Anitha Rajendiranb, Abu Raghavan Srinivasanb, Pruthu Gowdac, Veni Subramanyamd
a Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Nagpur, Maharashtra, India
b Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India
c Department of Community Medicine, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India
d Central Interdisciplinary Research facility, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India

Introduction: Hypertension represents the major risk factor for cardiovascular diseases. Pre-hypertensives are more likely to progress to hypertension. The mechanism for the progression of pre-hypertension to hypertension remains unclear. Hence the present study was designed to investigate the association of endothelin-1 with oxidative stress and inflammatory response in pre-hypertensives.

Methods: The study was conducted in thirty subjects with pre-hypertension and thirty normotensive subjects. Lipid profile, lipid bound sialic acid (LBSA), malondialdehyde (MDA) and endothelin-1 (ET-1) levels were estimated in the fasting blood samples.

Results: Total cholesterol, triacylglycerol (TAG), very low density lipoprotein cholesterol (VLDL-c) and low density lipoprotein cholesterol (LDL-c) were significantly increased in pre-hypertensives. LBSA (39.58 ± 4.35), ET-1 (13.43 ± 5.1) and MDA (1.78 ± 3.5) were also significantly elevated in pre-hypertensives when compared to normotensive subjects. ET-1 was significantly correlated with LBSA and MDA in pre-hypertensives. Receiver operating curve analysis of ET-1, LBSA and MDA showed cut off values of 7.0, 31.5 and 1.23 respectively for the diagnosis of pre-hypertension.

Conclusion: Elevated ET-1, LBSA and oxidative stress are associated with altered blood pressure in pre-hypertensives and may progress to essential hypertension.

Keywords: Endothelin-1, LDL-c, Lipid bound sialic acid, Malondialdehyde, Pre-hypertension

Received: February 4, 2019; Accepted: March 27, 2019; Published: December 15, 2019  Show citation

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Gopal N, Maithilikarpagaselvi N, Rajendiran A, Raghavan Srinivasan A, Gowda P, Subramanyam V. Association of endothelin-1 with oxidative stress and inflammatory response in pre-hypertensives. Cor Vasa. 2019;61(6):562-566. doi: 10.33678/cor.2019.048.
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