Cor Vasa 2017, 59(1):e42-e50 | DOI: 10.1016/j.crvasa.2017.01.014

Novel TAVI designs

Jan Kovac^a,*, Julia H. Baron^b, Hasan Jilaihawi^c, Derek T. Chin^a

^a University Hospitals of Leicester NHS Trust, Leicester, United Kingdom

^b Royal Derby Hospital, Derby, United Kingdom

^c New York University, Langtone Medical Center, New York

"Novel" TAVI valves is a rapidly developing area. Since concept of TAVI was resolutely established in randomised trials with first generation valves, there was tremendous engineering development and finesse, enabling to achieve excellent acute and mid-term haemodynamic result with largely minimal aortic regurgitation, typically no residual gradient and miniaturisation enabling substantial majority of patients to be treated via transfemoral approach. To ease operator comfort designs enable reposionability or one attempt precision increasing acute safety. As current and future trials will bring this technology to broader spectrum of patients group, vigilance is required re long-term durability of valves, possibly further miniaturisation, especially for non transfemoral access, development of yet user friendly closure devices (single step), optimal anticoagulation post procedure, eventually cerebral protection and modification designs to further reduce requirement for cardiac pacing.

Keywords: Severe aortic stenosis; Transcatheter aortic valve implantation

Received: December 14, 2016; Accepted: January 12, 2017; Published: February 1, 2017  Show citation