Cor Vasa 2016, 58(5):e509-e512 | DOI: 10.1016/j.crvasa.2015.12.002

Invasive aspergillosis following the heart transplantation - A case report

Július Godava^a,b,*, Jan Krejčí^a,b, Petr Hude^a,b, Eva Ozábalová^a,b, Tomáš Honek^a,b, Petr Němec^c, Michal Tichý^d, Marta Pažourková^e, Lenka Špinarová^a,b

^a I. interní kardioangiologická klinika, Fakultní nemocnice u sv. Anny v Brně - International Clinical Research Center, Brno, Česká republika

^b Lékařská fakulta Masarykovy univerzity, Brno, Česká republika

^c Centrum kardiovaskulární a transplantační chirurgie, Brno, Česká republika

^d I. patologicko-anatomický ústav, Fakultní nemocnice u sv. Anny v Brně, Brno, Česká republika

^e Klinika zobrazovacích metod, Fakultní nemocnice u sv. Anny v Brně, Brno, Česká republika

According to the ISHLT registry infectious complications are the leading cause of death in the first year after heart transplantation. Presented case report describes the fate of 63-year-old patient with heart failure due to coronary artery heart disease, which in March 2012, underwent a heart transplantation. In May he comes with symptoms of respiratory infection. Diagnosed invasive aspergillus pneumonia, for which deployed specific treatment with voriconazole. For unsatisfactory effect enhanced by the addition of amphotericin B. Despite all the care patient a month after diagnosis died of sepsis. A subsequent autopsy found the cause of death: abscessing necrotizing bronchopneumonia, but the surprise was the absence of fungal elements both by microscopy and cultivation.

Keywords: Heart transplantation; Invasive aspergillosis; Voriconazole

Received: September 15, 2015; Revised: December 7, 2015; Accepted: December 7, 2015; Published: October 1, 2016  Show citation