Cor Vasa 2010, 52(5-6):353-356 | DOI: 10.33678/cor.2010.088

Plasmatic levels of inflammatory markers during cardiopulmonary bypass in hypothermia and normothermia

Jiří Slavík^*, Marie Bobková, Karel Medek, Jitka Nešporová, Blanka Píchovcová, Jan Černý, Petr Němec

Centrum kardiovaskulární a transplantační chirurgie, Brno, Česká republika

Introduction: The aim of our study is to find out if normothermia during cardiopulmonary bypass (CPB) decreases the intensity of systemic inflammatory response in patients compared with mild hypothermia around 30 °C. An important marker of the stress reaction during CPB is cytokine production.

Methods: The plasmatic levels of diferent cytokines were measured eight times before, during, and after cardiac surgery. Two groups of patients - normothermic (n = 23) and hypothermic (n = 20) - undergoing elective coronary revascularisation were compared. We measured and compared the plasmatic levels of the following cytokines: TNF-α, interleukins IL-1-β, IL-6, IL-8, IL-10, endothelin ET-1, intracellular adhesion molecule ICAM-1, vascular cell adhesion molecule VCAM-1 and L-selectin.

Results: We found significantly decreased levels of proinflammatory cytokines (TNF-α, IL-6 and IL-8) and increased level of the antiinflammatory cytokine IL-10 in the normothermic group in comparison with the hypothermic group.

Conclusions: As for the development of a systemic inflammatory response, normothermia appears less harmful in comparison with hypothermia.

Keywords: Systemic Inflammatory Response Syndrome; Cytokine production; Cardiopulmonary Bypass; Normothermia; Hypothermia

Published: May 1, 2010  Show citation