Cor Vasa 2007, 49(2):46-54 | DOI: 10.33678/cor.2007.021

Autologous transplantation of mononuclear bone marrow cells in patients with chronic myocardial infarction

Jaroslav Meluzín^1,*, Stanislav Janoušek², Jiří Mayer³, Ladislav Groch¹, Jan Sitar¹, Miloslav Tejc¹, Petr Kala², Roman Panovský¹, Milan Kamínek⁴, Martin Klabusay⁴, Zdeněk Kořístek⁴, Ladislav Dušek⁵

¹ I. interní-kardioangiologická klinika, Fakultní nemocnice u sv. Anny

² Interní a kardiologická klinika

³ Interní-hematoonkologická klinika, Masarykova univerzita, Brno

⁴ Oddělení nukleární medicíny, Fakultní nemocnice Olomouc, Olomouc

⁵ Centrum biostatiky a analýz, Masarykova univerzita, Brno, Česká republika

Aim:
The aim of this study was to evaluate the efficacy and safety of intracoronary autologous mononuclear bone marrow (MBM) cell transplantation in patients with chronic myocardial infarction (MI).

Methods:
Of the first 31 patients treated with intracoronary autologous MBM cell transplantation in the acute phase of MI, 13 exhibited functional improvement (but not normalization of wall motion) at a 3-month follow-up visit and agreed with repeat cell transplantation. They were randomized to either repeat MBM cell transplantation (n = 7) or to a 3-month control group (n = 6).

Results:
Three adverse effects occurred in association with repeat cell transplantation. Two of these were immediately related to repeat balloon dislocation on a smooth surface of the stent covered with intimal proliferation forming an insignificant restenosis. These dislocations occurred during repeat balloon inflations in the course of cell implantation and resulted in intimal dissection and myocardial damage. The third patient was found to have an isolated increase in troponin I following the procedure. Six-month follow-up results revealed no improvement in myocardial function and perfusion in the infarcted area. Frequent procedure-related side effects and no obvious benefit of cell transplantation resulted in premature termination of the study.

Conclusion:
Repeat intracoronary autologous MBM cell transplantation in patients with chronic MI may be associated with relatively frequent procedure-related side effects and does not seem to provide any obvious benefit to the patients.

Keywords: Cell transplantation; Myocardial infarction; Stem cells

Published: February 1, 2007  Show citation