Cor Vasa 2011, 53(10):559-562 | DOI: 10.33678/cor.2011.138

Historical and current clinical usage of verapamil, beta-blockers and their mutual combinations in arrhythmology

Peter Hanák*, Radek Jančár, Marcel Heczko, Radim Kryza
Interní oddělení, Městská nemocnice Ostrava, Ostrava, Česká republika

Review of combinations of verapamil, bisoprolol and moxonidine in 22-year-old hypertensive man is presented, and significant sympto-matic pro-arrhythmogenic effect of this treatment is mentioned. Whole range of secondary - iatrogenic - arrhythmias is described in this case report. Disordered impulse formation and conduction, activation of alternate pacemakers and ectopic pacemakers were all seen in this patient. The observed dysrhythmias were fully reversible, with a restitution of sinus rhythm within 48 hours of pro-arrhythmogenic antihypertensives discontinuation. Therapeutic use of the combination of verapamil and beta-blockers in arrhythmology is risky; this combination should only be used during hospitalization with permanent monitoring and slow dose titration (especially with beta-blockers), provided that other forms of treatment had failed.

Keywords: Verapamil; Beta-blockers; Combined treatment; Arrhythmia; Pro-arrhythmogenic effect

Published: October 1, 2011  Show citation

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Hanák P, Jančár R, Heczko M, Kryza R. Historical and current clinical usage of verapamil, beta-blockers and their mutual combinations in arrhythmology. Cor Vasa. 2011;53(10):559-562. doi: 10.33678/cor.2011.138.
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