Cor Vasa 2010, 52(3):176-182 | DOI: 10.33678/cor.2010.045

Resynchronization therapy in patients with chronic heart failure - hemodynamic changes

Eva Ozábalová1,*, Miroslav Novák1, Jan Krejčí1, Petr Hude1, Jolana Lipoldová1, Jaroslav Meluzín1, Pavel Vank2, Jiří Vítovec1
1 I. interní kardioangiologická klinika, Fakultní nemocnice u sv. Anny a Lékařská fakulta Masarykovy univerzity, Brno
2 Klinika funkční diagnostiky a rehabilitace, Fakultní nemocnice u sv. Anny, Brno, Česká republika

Aim: The aim of this study was to assess the early (at 3 months) and late (at 12 months) therapeutic effect of biventricular pacing in symptomatic patients with chronic heart failure despite adequate pharmacotherapy, with special emphasis on modulation of hemo-dynamic parameters.

Patients and methods: A total of 118 patients with chronic heart failure (NYHA functional class II-IV, left ventricular ejection fraction [LVEF] 20.5±5.3%, mean age, 62.17±5.68 years) had biventricular devices implantation in the 2000-2006 period. Left bundle branch block and prolonged QRS complex (duration, 160.28±25.05 ms) on ECG were present.
Changes in hemodynamic parameters in right-heart catheterization, maximal exercise capacity by spiroergometry, echocardiographic parameters, NYHA functional class were compared after 3 and 12 months with biventricular pacing. We sought for any complications after biventricular device implantation, reasons for hospitalization, and changes in pharmacotherapy.

Results: A total of 77 biventricular pacemakers and 41 biventricular cardioverter-defibrillators were implanted. Leads for the left ventricle were successfully inserted via the coronary sinus in 111 patients, with another seven patients having epicardial lead implantation (under general anesthesia) through left lateral mini-thoracotomy.
Comparison of parameters obtained before implantation, and at 3 and 12 months after implantation was performed in 66 patients. There was significant improvement in NYHA functional class (from 2.8±0.4 to 2.3±0.5 after 3 m, p

Keywords: Chronic heart failure; Cardiac resynchronization therapy; Left bundle branch block; Right-heart catheterization

Published: March 1, 2010  Show citation

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Ozábalová E, Novák M, Krejčí J, Hude P, Lipoldová J, Meluzín J, et al.. Resynchronization therapy in patients with chronic heart failure - hemodynamic changes. Cor Vasa. 2010;52(3):176-182. doi: 10.33678/cor.2010.045.
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