Cor Vasa 2008, 50(12):460-463 | DOI: 10.33678/cor.2008.169

The role of microRNAs in cardiovascular disease

Martin Pěnička*, Karel Vondrák
III. interní-kardiologická klinika, Kardiocentrum, Fakultní nemocnice Královské Vinohrady a 3. lékařská fakulta Univerzity Karlovy, Praha, Česká republika

Recent experimental work has highlighted the enormous importance of what is referred to as microRNAs in the post-transcriptional regulation of gene expression. MicroRNAs are single-stranded RNA molecules of about 22 nucleotides in length belonging to the family of non-coding RNA. MicroRNAs induce a decrease in "messenger" RNA thereby inhibiting protein synthesis at translation level. The only specific type of microRNAs regulates the expression of a whole chain of genes encoding functionally or structurally related proteins. Experimental work has identified microRNAs as key regulators of genes affecting the growth and hypertrophy of cardiomyocytes, their contractile function, and electrical conductivity. This review article summarizes current concepts regarding the relevance of microRNAs in heart development and pathogenesis of cardiovascular disease.

Keywords: MicroRNA; Cardiovascular disease; Myocardial hypertrophy; Myocardial infarction; Arrhythmias

Published: December 1, 2008  Show citation

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Pěnička M, Vondrák K. The role of microRNAs in cardiovascular disease. Cor Vasa. 2008;50(12):460-463. doi: 10.33678/cor.2008.169.
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