Cor Vasa 2005, 46(1):22-24

New data regarding endotelin-1 and atrial natriuretic factor in pulmonary hypertension

Helena Sládková*, Zdeněk Susa, Pavel Jansa, Michael Aschermann, Miroslav Pšenička, Antonín Jindra, Marie Jáchymová
II. interní klinika, Všeobecná fakultní nemocnice a 1. lékařská fakulta Univerzity Karlovy, Praha, Česká republika

We assessed the levels of endothelin-1 (ET-1) and atrial natriuretic factor (ANF) at rest and during inhalation of a hypoxic mixture in 11 patients with pulmonary hypertension (as against a control group without pulmonary hypertension). The levels of ET-1 and ANF in patients with pulmonary hypertension tend to increase during hypoxia. Both ET-1 and ANF are expressed in the pulmonary vascular bed. Our results are consistent with literary data and confirm that ET-1 and ANF play a role not only in systemic but, also, in pulmonary hypertension. The finding of arterial ANF levels higher than pulmonary arterial levels is a new and surprising one, suggesting pulmonary ANF expression.

Keywords: Pulmonary hypertension; Endothelin-1; Atrial natriuretic factor

Published: January 1, 2005  Show citation

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Sládková H, Susa Z, Jansa P, Aschermann M, Pšenička M, Jindra A, Jáchymová M. New data regarding endotelin-1 and atrial natriuretic factor in pulmonary hypertension. Cor Vasa. 2005;46(1):22-24.
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