Cor Vasa 2004, 45(8):384-388
Autologous bone marrow cell transplantation in a patient with acute myocardial infarction
- 1 I. interní-kardioangiologická klinika, Fakultní nemocnice u sv. Anny
- 2 Interní-hematoonkologická klinika
- 3 Oddělení nukleární medicíny, Fakultní nemocnice Brno
- 4 Klinika nukleární medicíny, Fakultní nemocnice Olomouc, Olomouc
- 5 Oddělení nukleární medicíny, Masarykův onkologický ústav
- 6 Tkáňová banka, Fakultní nemocnice Brno, Brno, Česká republika
The aim of this communication is to report and analyze the case of a patient with moderate to severe myocardial infarction (left ventricular ejection fraction 28%), treated by primary coronary angioplasty with stent implantation, in whom autologous bone marrow cell transplantation resulted in significant improvement in function, perfusion, and metabolism of myocardial segments sustaining originally irreversible injury. The presence of irreversible injury to the infarct focus was confirmed both by dobutamine stress echocardiography, gated technetium-99m sestamibi SPECT, and positron emission tomography (PET). Cell transplantation was performed on post-infarction day 7 using an intracoronary catheter delivering 1 × 108 mononuclear bone marrow cells into the infarct-related artery. At 3 months after cell transplantation, echocardiography, SPECT and PET demonstrated marked improvement in function, perfusion and metabolism in all areas of myocardial infarction including its central part. The present paper documents the potential for effective regeneration of the myocardium even after it has sustained relatively extensive injury, and discusses the possible causes of this phenomenon.
Keywords: Autologous cell transplantation; Myocardial infarction; Myocardial regeneration
Published: August 1, 2004 Show citation