Cor Vasa 2018, 60(2):e148-e154 | DOI: 10.1016/j.crvasa.2017.05.018

Biomarkers of renal function in prognostic stratification of patients with acute coronary syndrome

Jan Přeček^a,*, Martin Hutyra^a, František Kováčik^a, Jiří Orság^b, Miloš Táborský^a

^a I. interní klinika - kardiologická, Lékařská fakulta Univerzity Palackého a Fakultní nemocnice Olomouc, Olomouc, Česká republika

^b III. interní klinika - nefrologie, revmatologie, endokrinologie, Lékařská fakulta Univerzity Palackého a Fakultní nemocnice Olomouc, Olomouc, Česká republika

There is close pathophysiological interaction between the kidneys and the heart, affecting, among others, the risk for development and prognosis of many cardiovascular diseases. Early risk stratification of patients with acute coronary syndrome (ACS) is important for optimizing their therapy. Presented is an overview of prognostic stratification of ACS patients according to baseline levels of renal function biomarkers. Apart from classic biomarkers (creatinine, urea) having a dominant role in advanced chronic kidney disease, some novel biomarkers are listed (cystatin C, neutrophil gelatinase-associated lipocalin, interleukin-18) that bring an added value as they are directly associated with the pathological mechanisms of the course of ACS.

Keywords: Acute coronary syndrome; Biomarkers; Creatinine; Glomerular filtration; NSTEMI; Prognostic stratification; Renal function; STEMI; Unstable angina; Urea; Cystatin C; NGAL; Interleukin-18

Received: March 21, 2017; Revised: May 30, 2017; Accepted: May 31, 2017; Published: April 1, 2018  Show citation