Cor Vasa 2017, 59(4):e416-e417 | DOI: 10.1016/j.crvasa.2017.03.012
The authors of lipid guidelines are at odds with their own recommendations
- Centrum preventivní kardiologie, III. interní klinika, 1. lékařská fakulta Univerzity Karlovy a Všeobecná fakultní nemocnice v Praze, Praha, Česká republika
In the era of evidence-based medicine, diagnostic and treatment guidelines prepared by professional societies, as well as expert opinions, constitute substantial guidance for practicing physicians. However, in a joint ESC/EAS publication, "Task Force consensus statement on proprotein convertase subtilisin/Kexin Type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk",' has caught a significant number of practicing physicians off guard and left them perplexed. Physicians are obliged to treat patients in accordance with the latest scientific findings, which those attempting to form legal interpretations often confuse as treatment according to guidelines. Therefore, an expert opinion should respect professional viewpoints and strive to maximize and accommodate all the various patients who stand to benefit from the use of a particular treatment, not just those patients most often studied.
Keywords: Cardiovascular risk; Familial hypercholesterolemia; LDL-C; Lp, a, ; PCSK9 inhibitors; Target levels of LDL-C
Received: February 2, 2017; Accepted: March 24, 2017; Published: August 1, 2017 Show citation
References
- U. Landmesser, M.J. Chapman, M. Farnier, et al., European Society of Cardiology/European Atherosclerosis Society Task Force consensus statement on proprotein convertase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk, European Heart Journal 2016 Oct 27. pii: ehw480. [Epub ahead of print].
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- A.L. Catapano, I. Graham, G. De Backer, et al., ESC/EAS Guidelines for the Management of Dyslipidaemias: the Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS), European Heart Journal 37 (2016) 2999-3058.
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- S.J. Nicholls, R. Puri, T. Anderson, et al., Effect of evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial, Journal of the American Medical Association 316 (2016) 1083-1092.
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