Cor Vasa 2011, 53(4-5):264-266 | DOI: 10.33678/cor.2011.059

Use of trimetazidine in preventing contrast-induced nephropathy: a nephrologist's perspective

Vladimír Teplan
Klinika nefrologie, Transplantcentrum, Institut klinické a experimentální medicíny a Subkatedra nefrologie, Institut postgraduálního vzdělávání ve zdravotnictví, Praha, Česká republika

Contrast-induced nephropathy (CIN) is a serious complication of coronary angiography potentially associated with increased morbidity and mortality, need for short-term hemodialysis, prolonged hospitalization, and renal failure. Studies designed to explore options in CIN prevention included trimetazidine (TMZ) belonging to cytoprotective anti-ischemic agents used in the treatment of angina. Trimetazidine affects reperfusion at the cellular and mitochondrial levels, and has antioxidant and metabolic activity via several mechanisms at the cellular level, that is, it shows characteristics making it a clear candidate for CIN prophylaxis.

Keywords: Contrast-induced nephropathy; Trimetazidine

Published: April 1, 2011  Show citation

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Teplan V. Use of trimetazidine in preventing contrast-induced nephropathy: a nephrologist's perspective. Cor Vasa. 2011;53(4-5):264-266. doi: 10.33678/cor.2011.059.
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