Cor Vasa 2011, 53(4-5):239-241 | DOI: 10.33678/cor.2011.053
Prevention of cardiovascular diseases in the obese
- III. interní klinika, 1. lékařská fakulta Univerzity Karlovy a Všeobecná fakultní nemocnice, Praha, Česká republika
The main risks associated with obesity are those related to metabolism and malignancy. Cardiovascular risks of obesity include the development of diabetes and metabolic syndrome in later life. Efforts at reducing obesity-related cardiovascular risk should focus on prevention of type-2 diabetes as well as comprehensive treatment of dyslipidemia, hypertension and, possibly, diabetes. Regular physical activity is just another major factor lowering the risks. Research in obesity has shown particularly decreased mortality rates after bariatric surgery. A phenomenon related to obesity and referred to as the obesity paradox shows that some conditions including heart failure and atrial fibrillation are associated with a brighter prognosis in the obese compared with the non-obese. Hence, cardiovascular risk reduction in the obese must be both comprehensive and individualized.
Keywords: Type 2 diabetes; Metabolic syndrome; Hypertension; Obesity paradox; Physical activity of the obese; Atrial fibrillation; Heart failure
Published: April 1, 2011 Show citation
References
- Jee SH, Sull JW, Park J, et al. Body-mass index and mortality in Korean men and women. N Engl J Med 2006;355:779-787.
Go to original source...
Go to PubMed...
- Adams KF, Schatzkin A, Harris TB, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006;355:763-778.
Go to original source...
Go to PubMed...
- Svačina Š. Metabolický syndrom. Praha: Triton, 2006.
- Suka M, Miwa Y, Ono Y, Yanagisawa H. BMI, waist circumference, and clustering of cardiovascular risk factors in Japanese adults. Environ Health Prev Med 2011;16:90-96.
Go to original source...
Go to PubMed...
- Isomaa B, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001;24:683-689.
Go to original source...
Go to PubMed...
- Svačina Š. Prevence diabetu a jeho komplikací. Praha: Triton, 2008.
- Svačina Š, Matoulek M. Vede významná redukce hmotnosti ke snížení krevního tlaku? Aretriální hypertenze současné trendy (ed. Widimský J.) Praha: Triton, 2011.
- Straznicky N, et al. European Society of Hypertension Working Group on Obesity Antihypertensive effects of weight loss: myth or reality? J Hypertens 2010;28:637-643.
Go to original source...
Go to PubMed...
- Lee CD, Blair SN, Jackson AS. Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am J Clin Nutr 1999;69:373-380.
Go to original source...
Go to PubMed...
- James WP, et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med 2010;363:905-917.
Go to original source...
Go to PubMed...
- Fried M, et. al. Bariatrická a metabolická chirurgie. Praha: Mladá fronta, 2011.
- Simpson JA, et al. A comparison of adiposity measures as predictors of all-cause mortality: the Melbourne Collaborative Cohort Study. Obesity (Silver Spring) 2007;15:994-1003.
Go to original source...
Go to PubMed...
- Dorner TE, Rieder A. Paradox obezity neboli reverzní epidemiologie. Vysoká tělesná hmotnost jako protektivní faktor při některých chronických stavech. Med Prom 2010;11:41-46.
- Svačina Š. Paradox obezity neboli reverzní epidemiologie - komenář. Med Prom 2010;11:46-47.
- McAuley P, Myers J, Abella J, Froelicher V. Body mass, fitness, and survival in veteran patients: another obesity paradox? Am J Med 2007;120: 518-524.
Go to original source...
Go to PubMed...
- Pingitore A, et al. The obesity paradox and myocardial infarct size. J Cardiovasc Med (Hagerstown) 2007;8:713-717.
Go to original source...
Go to PubMed...
- Kaiser R, et al. Functionality and mortality in obese nursing home residents: an example of "risk factor paradox"? J Am Med Dir Assoc 2010;11: 428-435.
Go to original source...
Go to PubMed...
- Badheka AO, et al. Influence of obesity on outcomes in atrial fibrillation: yet another obesity paradox. Am J Med 2010;123:646-651.
Go to original source...
Go to PubMed...