Cor Vasa 2010, 52(Suppl.):48-51 | DOI: 10.33678/cor.2010.205

Fibrinolytic inhibitors in cardiac surgery - a view from the end of the first decade of the new millennium

Tomáš Vaněk*, Ján Špegár, Jana Šnircová
Kardiochirurgická klinika, Kardiocentrum, Fakultní nemocnice Královské Vinohrady a 3. lékařská fakulta Univerzity Karlovy, Praha, Česká republika

Preventive application of fibrinolytic inhibitors in cardiac surgery has been used to reduce perioperative blood loss and transfusion requirements since the 1980s. The article describes the history of introducing aprotinin into practice and deals with the circumstances leading to its recent withdrawal from the pharmaceutical market. It briefly summarizes the current view on synthetic lysine analogs both in cardiac surgery and other fields of surgery.

Keywords: Cardiac surgery; Fibrinolysis; Fibrinolytic inhibitors; Aprotinin; Tranexamic acid

Published: December 1, 2010  Show citation

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Vaněk T, Špegár J, Šnircová J. Fibrinolytic inhibitors in cardiac surgery - a view from the end of the first decade of the new millennium. Cor Vasa. 2010;52(Suppl.):48-51. doi: 10.33678/cor.2010.205.
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