Cor Vasa 2009, 51(7-8):513-519 | DOI: 10.33678/cor.2009.127

Intracoronary delivery of stem cells in patients with acute myocardial infarction. The clinical experience obtained to date and prospects

Hana Skalická jr.1,*, Jan Horák1, Michael Aschermann1, Aleš Linhart1, Petr Kobylka2
1 2. interní klinika kardiologie a angiologie, Všeobecná fakultní nemocnice a 1. lékařská fakulta Univerzity Karlovy
2 Oddělení buněčné terapie, Ústav klinické a experimentální hematologie, 1. lékařská fakulta Univerzity Karlovy a Ústav hematologie a krevní transfuze, Praha, Česká republika

The paper is an overview of results of landmark clinical trials addressing the issue of mononuclear bone marrow stem cell implantation in patients with a major acute myocardial infarction and severe post-MI left ventricular dysfunction. Worldwide research has focused on this topic for a couple of years. Most importantly, it is hoped to be able to block the process of progressive left ventricular remodeling by replacing the necrotic or fibrotic myocardium by contractile tissue thereby precluding the development of heart failure. Attention has particularly centered on patients not resuming contractile function immediately after the event; despite all recent advances in medicine, their long-term prognosis is often fairly poor.

Keywords: Acute myocardial infarction; Stem cells; Left ventricular remodeling; Mononuclear bone marrow cells; Left ventricular ejection fraction

Published: July 1, 2009  Show citation

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Skalická H, Horák J, Aschermann M, Linhart A, Kobylka P. Intracoronary delivery of stem cells in patients with acute myocardial infarction. The clinical experience obtained to date and prospects. Cor Vasa. 2009;51(7-8):513-519. doi: 10.33678/cor.2009.127.
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