Cor Vasa 2008, 50(12):480-485 | DOI: 10.33678/cor.2008.173

The TIMI trials - 25 years of clinical research (1984-2009)

Jindřich Špinar^1,*, Jiří Vítovec², Lenka Špinarová²

¹ Interní klinika, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity

² I. interní kardioangiologická klinika, Fakultní nemocnice u sv. Anny a Lékařská fakulta Masarykovy univerzity, Brno, Česká republika

The TIMI group has celebrated 25 years of its existence and 50 clinical trials conducted during the American Heart -Association (AHA) Annual Meeting held in New Orleans in November 2008. The TIMI group was founded in 1984, with Professor Eugene Braunwald being the leading cardiologist of the group since the very beginning. TIMI has evolved into a wide array of phase I to phase IV trials as well as registries. These have ranged in size from less than 30 to more than 300,000 subjects.
The TIMI group has formulated several definitions in cardiology, e.g., the myocardial infarction definition, TIMI bleeding definition, TIMI flow grade (perfusion grade) definition, TIMI thrombus grade definition, TIMI risk scores, and others.
Results of the trials conducted by TIMI group have changed the daily practice of cardiology all over the world. The Czech Republic is proud to be part of the TIMI group and TIMI trials.

Keywords: TIMI; Clinical trials; Myocardial infarction; Bleeding; Blood flow; Risk score

Published: December 1, 2008  Show citation