Cor Vasa 2008, 50(6):246-253 | DOI: 10.33678/cor.2008.081

Thrombolytic therapy in acute pulmonary embolism

Vladimír Dytrych, Jan Bělohlávek, Tomáš Kovárník, Pavel Jansa, Aleš Linhart, Michael Aschermann
II. interní klinika kardiologie a angiologie, Všeobecná fakultní nemocnice a 1. lékařská fakulta Univerzity Karlovy, Praha, Česká republika

Acute pulmonary embolism is a relatively frequent condition with a variable clinical course. The authors discuss in detail the current indications for thrombolytic therapy in patients with this condition and the relevance of risk stratification, which should play the pivotal role in future therapeutic decision-making.

Keywords: Acute pulmonary embolism; Thrombolytic therapy; Risk stratification

Published: June 1, 2008  Show citation

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Dytrych V, Bělohlávek J, Kovárník T, Jansa P, Linhart A, Aschermann M. Thrombolytic therapy in acute pulmonary embolism. Cor Vasa. 2008;50(6):246-253. doi: 10.33678/cor.2008.081.
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    References

    1. Widimský J, Malý J a spol. Akutní plicní embolie a žilní trombóza. Patogeneze, diagnostika, léčba a prevence. 2. rozšířené a přepracované vydání. Praha: Triton, 2005:381.
    2. Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet 1999;353:1386-9. Go to original source... Go to PubMed...
    3. Kasper W, Konstantinides S, Geibel A, et al. Management strategies and determinants of outcome in acute major pulmonary embolism: results of a multicenter registry. J Am Coll Cardiol 1997;30:1165-71. Go to original source... Go to PubMed...
    4. Riberio A, Lindmarker P, Juhlin-Dannfelt A, et al. Echocardiography Doppler in pulmonary embolism: right ventricular dysfunction as a predictor of mortality rate. Am Heart J 1997;134:479-87. Go to original source... Go to PubMed...
    5. Kucher N, Rossi E, Goldhaber S, et al. Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mmHg or higher. Arch Intern Med 2005;165:1777-81. Go to original source... Go to PubMed...
    6. Schoepf J, Kucher N, Kipfmueller F, et al. Right ventricular enlargement on chest computed tomography. A predictor of early death in acute pulmonary embolism. Circulation 2004;110:3276-80. Go to original source... Go to PubMed...
    7. Widimský J. Akutní plicní embolie - nové trendy v diagnostice a léčbě. Postgraduální medicína 2006;8:248-54.
    8. Giannitsis E, Muller-Bardorff M, Kurowski V, et al. Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism. Circulation 2000;102:211-7. Go to original source... Go to PubMed...
    9. Konstantinides S, Geibel A, Olschewski M, et al. Importance of cardiac troponins I and T in risk stratification of patients with acute pulmonary embolism. Circulation 2002;106:1263-8. Go to original source... Go to PubMed...
    10. Janata K, Holzer M, Laggner A. Cardiac troponin T in the severity assessement of patients with pulmonary embolism: cohort study. Br Med J 2003;326:312-3. Go to original source... Go to PubMed...
    11. Kucher N, Printzen G, Goldhaber S. Prognostic role of brain natriuretic peptide in acute pulmonary embolism. Circulation 2003;107:2545-7. Go to original source... Go to PubMed...
    12. Torbicki A, Beek E, Charbonnier B, Meyer G, et al. Guidelines on diagnosis and management of acute pulmonary embolism. Euro Heart J 2000;21:1301-6. Go to original source... Go to PubMed...
    13. Widimský J, Malý J. Doporučení diagnostiky a léčby plicní embolie. Cor Vasa 2001;43:158-84.
    14. Kanter D, Mikkola K, Patel S, et al. Thrombolytic therapy for pulmonary embolism. Frequency of intracranial hemorrhage and associated risk factors. Chest 1997; 111:1241-5. Go to original source... Go to PubMed...
    15. Wan S, Quinlan D, Agnelli G, et al. Thrombolysis Compared With Heparin for the Initial Treatment of Pulmonary Embolism A Meta-Analysis of the Randomized Controlled Trials. Circulation 2004;110:744-9. Go to original source... Go to PubMed...
    16. Dalen J, Alpert J, Hirsch J. Thrombolytic therapy for pulmonary embolism: is it effective? Is it safe? When is it indicated? Arch Intern Med 1997;157:2550-6. Go to original source...
    17. Gore J, Sloan M, Price T, et al. Intracerebral hemorrhage, cerebral infarction and subdural hematoma after acute myocardial infarction and thrombolytic therapy in the Thrombolysis in Myocardial Infarction, Phase II, pilot and clinical trial. Circulation 1991;83:448-59. Go to original source... Go to PubMed...
    18. Levine M, Raskob G, Landefeld S, et al. Hemorhagic complications of anticoagulant treatment. Chest 2001; 119:108-21. Go to original source... Go to PubMed...
    19. Konstantinides S, Geibel A, Heusel G, et al. Heparin plus alteplase compared with heparin alone in patients with submassive pumonary embolism. N Engl J Med 2002;347:1143. Go to original source... Go to PubMed...
    20. Bailen M, Cuadra J, Aguayo H. Thrombolysis during cardiopulmonary resuscitation in fulminant pulmonary embolism: a review. Crit Care Med 2001;29:2211-9. Go to original source...
    21. Škulec R, Bělohlávek J, Kovárník T, et al. První zkušenosti s indukcí mírné hypotermie u nemocných po srdeční zástavě. Cor Vasa 2005;6:235-41.
    22. Bottiger B, Bode C, Kern S, et al. Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation: a prospective clinical trial. Lancet 2001;357:1583-5. Go to original source... Go to PubMed...
    23. Fatovich D, Dobb G, Cluqston R. A pilot randomised trial of thrombolysis in cardiac arrest (The TICA trial). Resuscitation 2004;61:309-13. Go to original source... Go to PubMed...
    24. Spohr F, Arntz H, Blumhki E, et al. International multicentre trial protocol to assess the efficacy and safety of tenecteplase during cardiopulmonary resuscitation in patients with out-of-hospital cardiac arrest: the Thrombolysis in Cardiac Arrest (TROICA) Study. Eur J Clin Invest 2007;35:315-23. Go to original source... Go to PubMed...
    25. Prusczyk P, Torbicki A, Kuch-Wocial A, et al. Diagnostic value of transesophageal echocardiography in suspected haemodynamically significant pulmonary embolism. Heart 2001;85:628-34. Go to original source...
    26. Jerjes-Sanchez C, Ramirez-Rivera A, de Lourdes Garcia M, et al. Streptokinase and Heparin versus Heparin Alone in Massive Pulmonary embolism: a Randomized Controlled Trial. J Thromb Thromb 1995;2:227-9. Go to original source...
    27. Kucher N, Rossi E, De Rosa M, et al. Massive pulmonary embolism. Circulation 2006;113:577-82. Go to original source... Go to PubMed...
    28. Dalla-Volta S, Palla A, Santolicandro A, et al. PAIMS 2: alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. J Am Coll Cardiol 1992;20:520-6. Go to original source...
    29. Goldhaber S, Haire W, Feldstein M, et al. Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion. Lancet 1993;341:507-11. Go to original source... Go to PubMed...
    30. Konstantinides S, Tiede N, Geibel A, et al. Comparison of alteplase versus Heparin for resolution of major pulmonary embolism. Am J Cardiol 1998;82:966-70. Go to original source... Go to PubMed...
    31. Cannon C, Goldhaber S. Cardiovascular risk stratification of pulmonary embolism. Am J Cardiol 1996;78: 1149-51. Go to original source...
    32. Hamel E, Pacouret G, Vincentelli D, et al. Thrombolysis or heparin therapy in massive pulmonary embolism with right ventricular dilation: results from a 128-patient monocenter registry. Chest 2001;120:120-5. Go to original source... Go to PubMed...
    33. Tissue plasminogen activator for the treatment of acute pulmonary embolism: a collaborative study by the PIOPED investigators. Chest 1990;97:528-33. Go to PubMed...
    34. Lualdi J, Goldhaber S. Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection, and therapeutic implications. Am Heart J 1995;130:1276-82. Go to original source... Go to PubMed...
    35. Widimský J. Trombolytická léčba i u normotenzních nemocných hemodynamicky stabilních s akutní plicní embolií? Interv Akut Kardiol 2005;4:66-8.
    36. Douketis J, Kearon C, Bates S, et al. Risk of fatal pulmonary embolism in patients with treated venous thrombembolism. JAMA 1998;279:458-62. Go to original source... Go to PubMed...
    37. Riedel M, Staněk V, Widimský J, et al. Long-term follow-up of patients with pulmonary thrombembolism. Late prognosis and evolution of haemodynamic and respiratory data. Chest 1982;81:151-8. Go to original source... Go to PubMed...
    38. Torbicki A, Galie N, Covezzoli A, et al. Right heart thrombi in pulmonary embolism: results from the International Cooperative Pulmonary Embolism Registry. J Am Coll Cardiol 2003;41:2245-52. Go to original source... Go to PubMed...
    39. Chapoutot L, Nazeyrollas P, Metz D, et al. Floating right heart thrombi and pulmonary embolism: diagnosis, outcome and therapeutic management. Cardiology 1996;87:169-74. Go to original source... Go to PubMed...
    40. Farfel Z, Shechter M, Vered Z, et al. Review of echocardiographically diagnosed right heart entrapment of pulmonary emboli-in-transit with emphasis on management. Am Heart J 1987;113:171-8. Go to original source... Go to PubMed...
    41. Justin P, Pierard L. Management of mobile right heart thrombi: a prospective series. Int J Card 2005;99:381-8. Go to original source... Go to PubMed...
    42. Schuchlenz H, Weihs W, Horner S, et al. The association between the diameter of a patent foramen ovale and the risk of embolic cerebrovascular events. Am J Med 2000; 109:456-62. Go to original source... Go to PubMed...
    43. Konstantinides S, Geibel A, Kasper W, et al. Patent foramen ovale is an important predictor of adverse outcome in patients with major pulmonary embolism. Circulation 1998;97:1946-51. Go to original source... Go to PubMed...
    44. Meneveau N, Schiele F, Vuillemenot A, et al. Streptokinase vs alteplase in masive pulmonary embolism. A randomized trial assesing right heart haemodynamics and pulmonary vascular obstruction. Eur Heart J 1997;18:1141-8. Go to original source... Go to PubMed...

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