Cor Vasa 2007, 49(12):463-465
The ADVANCE trial published. A fixed perindopril/indapamide combination for all patients with diabetes?
- Klinika kardiologie, Institut klinické a experimentální medicíny, Subkatetra kardiologie IPVZ, Praha, Česká republika
The ADVANCE trial is the largest randomized prospective study in type-2 diabetes. The trial compared the effects of addition of a fixed combination of perindopril/indapamide to current treatment versus placebo in over 11,000 patients with diabetes. Active therapy resulted in a significant decrease in macrovascular and microvascular complications as the primary endpoint of the trial. There was also a significant decrease in total and cardiovascular mortality. The total number of coronary events likewise fell significantly. Further, this therapy led to a significant decrease in new-onset microalbuminuria. The main mechanism is thought to be blood pressure lowering, with a role in the outcome also played by the cardioprotective and nephroprotective effects of the fixed combination of perindopril/indapamide.
Keywords: ADVANCE trial; Type-2 diabetes mellitus; Hypertension
Published: December 1, 2007 Show citation
References
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