Cor Vasa 2007, 49(6):213-215 | DOI: 10.33678/cor.2007.078
Effect of ghrelin variants on weight loss after dietary/exercise intervention
- Institut klinické a experimentální medicíny, Centrum výzkumu kardiovaskulárních onemocnění, Praha, Česká republika
Introduction:
Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body s energy balance. We have analyzed the association of ghrelin variants with body weight changes after dietary/exercise intervention in healthy overweight females.
Methods:
Ghrelin variants Arg51 > Gln, Leu72 > Met and Gln90 > Leu were analyzed by PCR-RFLP in 80 overweight (BMI 31.1 ± 3.0 kg/m2) females aged 25-55 years. Development of body weight and plasma lipids were analyzed in subgroups divided according to ghrelin genotypes.
Results:
Carriers of the Met72Met genotype were resistant to dietary/exercise intervention. They lost 1.5 kg compared to Leu72 carriers (5.3 kg). Other variants had no effect on body weight changes. Plasma lipids were not changed significantly between subgroups divided according to ghrelin variants.
Conclusions:
Common variants in ghrelin may have an effect on changes of body weight after behavioral intervention. However, the frequency of Met72Met carriers in the population is very low and results need to be confirmed in future studies.
Keywords: Ghrelin; Genetic polymorphism; Body weight; Diet; Exercise
Published: June 1, 2007 Show citation
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