Cor Vasa 2007, 49(4):152-154

Tissue factor and the soluble ligand CD40 in patients with acute coronary syndrome

Jan Vojáček¹, Josef Bis¹, Jaroslav Dušek¹, Vladimír Palička³, Ctirad Andrys⁴, Miroslav Pecka², Jaroslav Malý²

¹ I. interní klinika

² II. interní klinika

³ Ústav klinické biochemie a diagnostiky

⁴ Ústav klinické imunologie a alergologie, Lékařská fakulta Univerzity Karlovy a Fakultní nemocnice Hradec Králové, Hradec Králové, Česká republika

The plasma levels of tissue factor (TF) and the soluble ligand CD40 (sLCD40) were assessed in the coronary sinus (CS), left coronary artery (LCA), and a peripheral vein (PV) of patients with acute coronary syndrome (Group A) and stable coronary artery disease (Group B). Altogether, 28 subjects (age 62.6 ± 10.3 years, 19 males, 9 females) were included into Group A and 24 patients (age 62.3 ± 8.1 years, 21 males, 3 females) into Group B. The plasma levels of sLCD40 were significantly higher in the CS of patients in Group A as compared to those in group B (9070.5 ± 4539.3 pg/mL vs. 6841.4 ± 3283.8 pg/mL, p = 0.026). Also the difference in sLCD40 between CS and LCA was significantly higher in Group A as compared to Group B (Figure 1). A significant linear correlation between the plasma levels of TF and sLCD40 was found (Figure 2). The plasma levels of sLCD40 in Group A showed a trend towards a non-significant increase on Day 7 as compared to Day 0 (Figure 3).

Keywords: Acute coronary syndrome; Tissue factor; Soluble ligand CD40

Published: April 1, 2007  Show citation