Cor Vasa 2004, 45(3):133-136

²⁰¹Tl and ^99mTc-MIBI gated SPECT in patients with large perfusion defects: comparison of 4D-MSPECT software with contrast left ventriculography

Milan Kamínek^1,*, Marcela Škvařilová², Jiří Ostřanský², Václav Hušák¹, Iva Metelková¹, Miroslav Mysliveček¹

¹ Klinika nukleární medicíny

² I. interní klinika, Fakultní nemocnice a Univerzita Palackého, Olomouc, Česká republika

The aim of this study was to evaluate the feasibility and accuracy of new quantitative software, 4D-MSPECT, in assessing left ventricular ejection fraction (LVEF) in patients with large perfusion defects. The difference in LVEF, as determined using ²⁰¹Tl and ^99mTc-MIBI gated SPECT, was also evaluated.
A total of 125 consecutive patients (98 men, 27 women, 59 with a history of myocardial infarction, mean age 63 ± 8 yrs) who underwent rest ^99mTc-MIBI (n = 78) and ²⁰¹Tl (n = 47) gated SPECT and contrast left ventriculography (LVG) were studied. The summed rest perfusion score (SRS) and the LVEF were assessed using 4D-MSPECT software. Correlation coefficients were high for all patients (r = 0.929), for a subgroup of patients with mild to moderate perfusion abnormality (SRS 4-8: r = 0.964, SRS 9-13: r = 0.923), for a subgroup of patients with large perfusion defects (SRS > 13, r = 0.936), and for ^99mTc-MIBI and ²⁰¹Tl studies (r = 0.921 and 0.929, respectively). In agreement with previous studies performed using Cedars QGS, LVEF measurement is feasible using 4D-MSPECT software in patients with large perfusion defects. ^99mTc-MIBI was not found to be superior over ²⁰¹Tl in LVEF measurement.

Keywords: Myocardial perfusion imaging; ²⁰¹Tl gated SPECT; Ejection fraction; 4D-MSPECT

Published: March 1, 2004  Show citation