Inzulínová rezistencia a body mass index

Cor Vasa 2004, 45(2):58-87

Insulin resistance and body mass index

Marica Krajčovičová-Kudláčková^1,*, Pavel Blažíček², Mária Dušinská¹: ¹ Slovenská zdravotnícka univerzita, Ústav preventívnej a klinickej medicíny; ² Nemocnica Ministerstva obrany, Bratislava, Slovenská republika

Obesity plays an important role in the development of insulin resistance. This metabolic abnormality leads to age-related diseases. Insulin resistance values were correlated with obesity and age. Insulin levels were assessed in adult subjects of the general population with different body mass index values from normal weight (BMI = 18.8-25.0, n = 84) through overweight (BMI = 25.1-30.0, n = 42) to obesity (BMI = 30.1-51.6, n = 42). Mean insulin and glucose levels as well as insulin resistance (HOMA) value are significantly increased in overweight and obese groups. Risk-related insulin resistance values were present in 57% of obese subjects vs. 1% of normal-weight and 10% of overweight subjects. Insulin resistance values correlate significantly positively with age in normal-weight and overweight groups. In obese subjects, this correlation was non-significant, i.e., the metabolic disorder occurred already in younger-age groups. Other factors of the insulin resistance syndrome (hyperglycemia, hypertension, hypertriglyceridemia, hypo-HDL-cholesterolemia) were found more frequently in obese subjects. The finding of predominantly risk-related insulin resistance values in obese subjects as well as their age independence document the important role played by obesity in the development of insulin resistance already in the younger-age groups.