Cor Vasa 2002, 43(11):481-486
Drug interactions of cyclosporine A
- 1 Klinika kardiologie
- 2 Pracoviště klinické farmakologie
- 3 Klinika kardiovaskulární chirurgie, Institut klinické a experimentální medicíny, Praha, Česká republika
Heart transplantation (HTx) is an established method for the treatment of patients with end-stage heart failure. Management of these patients is characterized by some specific features, most importantly, as regards the management of immunosuppression. The immune response is suppressed by a combination of drugs including cyclosporine A. The association between the dose of cyclosporine A and its plasma levels is affected by a variety of factors and numerous drugs. The present paper addresses the issue of drug interactions observed in our patients. In clinical practice, it is critical to consider carefully any change in medication in the transplant recipient. A sufficient body of information on the potential interaction between cyclosporine A and other drugs is a conditio sine qua non should long-term immunosuppression succeed.
Keywords: Heart transplantation; Immunosuppressive therapy; Interaction with cyclosporine A
Published: November 1, 2002 Show citation