Cor Vasa 2002, 43(2):92-94

Temporary cyclosporin withdrawal in a patient after heart transplantation during chemotherapy for post-transplant lymphoproliferative disease

Mariana Podzimková^1,*, Ivan Málek¹, Petr Frídl¹, Tomáš Kozák²

¹ Klinika kardiologie, Institut klinické a experimentální medicíny

² Oddělení klinické hematologie, Fakultní nemocnice Královské Vinohrady, Praha, Česká republika

A patient undergoing orthotopic heart transplantation, performed in 1986, had post-transplant lymphoproliferative disease with two relapses. The disease became manifest in 1995, 9 years after surgery, with the first and second relapses occurring in 1999 and 2001, respectively. First-line therapy included CHOP combination therapy, to be replaced by the more aggressive Pro MACE Cyta BOM protocol after the first relapse. The second course of chemotherapy was associated with cyclosporin withdrawal. No signs of rejection were identified in any of the biopsy specimens obtained from the patient.

Keywords: Orthotopic heart transplantation; Posttransplant lymphoproliferative disease; Combination chemotherapy; Immunosuppressive therapy

Published: February 1, 2002  Show citation