A Rare Case of Acute Limb Ischemia due to Left Ventricular Thrombus in Ischemic Heart Disease: Different Approaches to Long-Term Anticoagulant and Antiplatelet TherapyCase reports

Meity Ardiana, Ovin Nada Saputri, Muhammad Surya Tiyantara, Michael Jonatan, Andrianto, Anudya Kartika Ratri

Cor Vasa 2025, 67(3):408-411 | DOI: 10.33678/cor.2024.044  

Left ventricular thrombus (LVT) may develop from the progression of coronary artery disease (CAD), which can rarely embolise and migrate to the peripheral artery. Here, we report the case of a 58-year-old man admitted to our hospital with a sudden onset of pain and numbness in his right lower limb, diagnosed as ALI. Unexpectedly, he also had silent and extensive CAD leading to heart failure with reduced ejection fraction (HFrEF) and LVT formation. LVT embolization in the peripheral artery was identified as the cause of ALI in this patient. Effective long-term antithrombotic therapy was necessary to reduce cardiovascular adverse events and disease progression....

Ketone Body in Heart Failure Patients with Diabetes: Pathophysiology and the Potential Therapeutic Benefit: a Literature ReviewReview articles

Hanestya Oky Hermawan, Primasitha Maharany Harsoyo, Faizal Ablansah Anandita, Aisya Ayu Shafira, Deasy Ardiany, Andrianto

Cor Vasa 2025, 67(3):402-407 | DOI: 10.33678/cor.2024.104  

Background: Common knowledge of heart failure treatment target is to intervene in the renin-angiotensin-aldosterone system and the sympathetic autonomic nervous system. However, metabolic aspect in the therapy of heart failure is rarely discussed. It is worth noting that heart failure often co-exist with diabetes. Thus, there is a need for a treatment that can be beneficial for these two diseases. During the pathophysiological transition to heart failure, metabolic abnormalities may occur, and lactic acid, ketone bodies, and amino acids may be used as alternative energy sources. Ketone body has been shown to be associated with these two diseases. Treatment...

Pelvic venous diseaseReview articles

Mária Rašiová, Martin Koščo, Marek Hudák, Veronika Pavlíková, Marta Bavoľárová

Cor Vasa 2025, 67(3):393-401 | DOI: 10.33678/cor.2025.059  

Pelvic venous disease is the second most common cause of chronic pelvic pain in women after endometriosis and accounts for 10-20% of gynecological consultations. Its main cause in women is reflux and incompetence of the left ovarian vein. In men, pelvic venous disease can manifest as varicocele and is often the result of venous obstruction in the iliocaval region. This article provides an overview of the symptoms, signs, dia- gnosis, and treatment of the most common causes of pelvic venous disease.

(The use of cardiac magnetic resonance in the stratification of patients with dilated cardiomyopathy)Review articles

Tatiana Štípalová, Roman Panovský, Mary Mojica-Pisciotti, Jan Krejčí

Cor Vasa 2025, 67(3):386-392 | DOI: 10.33678/cor.2025.038  

Dilated cardiomyopathy (DCM) is one of the most common multifactorial cardiomyopathies that manifests mostly as heart failure with an increased risk of ventricular arrhythmias and/or sudden cardiac death.¹ Detailed characterization of this process plays a key role in the prognostic stratification of DCM patients and in improving clinical therapy. applicability of standard and emerging CMR techniques.

(Constrictive pericarditis after SARS-CoV-2 vaccination: a case report and literature review)Review articles

Veronika Šimovičová, Marcela Danková, Erika Drangová, Michal Hulman, Eva Gonçalvesová

Cor Vasa 2025, 67(3):381-385 | DOI: 10.33678/cor.2024.107  

Constrictive pericarditis following SARS-CoV-2 vaccination is likely to be very rare and is characterized by a relatively severe clinical manifestation. We describe the case of a 42-year-old patient, without significant comorbidities, who developed perimyocarditis after the second dose of the COVID-19 vaccine. It was treated with nonsteroidal anti-inflammatory drugs. Six months after the perimyocarditis episode, the patient presented signs and symptoms of heart failure. A suspicion of constrictive pericarditis was raised. The diagnosis was confirmed by echocardiography, which showed typical signs of constriction, and cardiac CT, revealing a thickened...

The Effect of Cigarette Exposure on Intima-Media Thickness (IMT) and VCAM-1 Expression in the Aorta of Mus musculus MiceOriginal research articles

Meity Ardiana, Andrianto, Hanestya Oky Hermawan, Primasitha Maharany Harsoyo, Bagas Setiawan Ihsan Zaini, Akbar Reza Muhammad

Cor Vasa 2025, 67(3):376-380 | DOI: 10.33678/cor.2025.015  

Background: Smoking remains one of the leading causes of endothelial dysfunction, which triggers the atherosclerotic process and contributes to various cardiovascular diseases. One marker of endothelial dysfunction is an increase in VCAM-1, a molecule that promotes monocyte aggregation and accelerates the development of atherosclerosis. Thickening of the intima-media layer (IMT) is also a common indicator of endothelial damage, frequently observed in smokers. The aim of this study is to investigate the effect of cigarette smoking on vascular cell adhesion molecule-1 (VCAM-1) levels and intima-media thickness (IMT). Methods: An experimental study with...

Efficacy of Left Atrial Radiofrequency Surgical Ablation in Patients with Atrial Fibrillation and Concomitant Cardiac Surgical PathologyOriginal research articles

Olha Shepetko-Dombrovska, Serhii Varbanets, Pavlo Shepetko-Dombrovskyi, Ivanna Zubovych, Nadiya Rudenko

Cor Vasa 2025, 67(3):367-375 | DOI: 10.33678/cor.2025.007  

Aim: The aim of the study was to determine the feasibility of left atrial surgical ablation in patients with atrial fibrillation and concomitant cardiovascular diseases. Methods: The experiment was conducted at the Scientific and Practical Medical Centre of Paediatric Cardiology and Cardiac Surgery, Adult Clinic (Kyiv, Ukraine, 2024). A total of 69 patients who underwent surgical treatment for atrial fibrillation and concomitant cardiovascular disease took part in the study. Results: It was found that after the procedure of left atrial surgical ablation of the atrial fibrillation focus, the sinus node was the rhythm driver in 45 patients (65% of all)....

Correlation of ITGB3 Gene rs5918T>C and APOA1 Gene rs1799837C>T Variants with Serum Lipid Profiles in Turkish Cypriot Patients with Coronary Artery DiseaseOriginal research articles

Cenk Conkbayir, Mahmut Cerkez Ergoren, Havva Cobanogullari, Ozlem Balcioglu, Irem Abras, Tengul Eminsel, Didem Melis Oztas, Burak Onal, Murat Ugurlucan, Sehime Gulsun Temel

Cor Vasa 2025, 67(3):360-366 | DOI: 10.33678/cor.2025.004  

Aim: The relationship between hypercholesterolemia, particularly elevated low density lipoprotein-cholesterol (LDL-C) levels and coronary artery disease is recognized by the evidence from previous epidemiologic studies. Importantly, genetic polymorphisms on different genes have been reported to be associated with plasma lipid levels. In this particular study, we aimed to investigate the relationship between the ITGB3 gene rs5918 T>C and APO-A1 gene rs1799837 C>T markers and serum lipid metabolism. Patients and methods: A total of 100 subjects with CAD and 250 healthy subjects were involved in the current study. A basic biochemical...

Value of peri-procedural lung ultrasound in predicting heart failure or left ventricular systolic dysfunction within 3 months in STEMI patients undergoing primary PCIOriginal research articles

Ahmed Talaat, Mohamed Abou El Ezz, Mohamed Mahmoud Abd El Ghany, Mohamed Abdel Meguid Mahdy, Kareem Mahmoud

Cor Vasa 2025, 67(3):350-359 | DOI: 10.33678/cor.2025.006  

Aim: To see if the detection of subclinical congestion in STEMI patients by lung ultrasound (LUS) could be helpful in predicting the development of future heart failure, systolic dysfunction or diastolic dysfunction. Methods: 150 patients were included. All patients were successfully revascularized and were not suffering from clinical heart failure on admission. The patients had a 28-point LUS study within the first 24 hours of admission, and B-lines were counted. Patients were divided into two groups: 64 patients into the LUS positive group (with 6 or more B-lines) and 86 into the LUS negative group. They were followed-up after 3 months, looking for...

Comparison of EuroSCORE II, STS Score, and ACEF II Score as Predictors of Mortality in CABG Patients at Tertiary Referral Hospital in East IndonesiaOriginal research articles

Yan Efrata Sembiring, Ali Mustofa, Andrianto, Heroe Soebroto

Cor Vasa 2025, 67(3):344-349 | DOI: 10.33678/cor.2025.005  

Background: Identifying the optimal surgical approach and therapy for a patient is an important step in the preoperative preparation process. Risk stratification models such as EuroSCORE II, STS score, and ACEF II score were created to assist in evaluating factors associated with surgical outcomes. This scoring models are now utilized to risk stratify patients having coronary artery bypass graft (CABG) surgery. However, it has not been determined which model is better for Indonesian patients. The purpose of this study was to compare EuroSCORE II, STS score, and ACEF II score in CABG patients from Indonesia. Methods: A cross-sectional study was conducted...

(Changes in Body Composition During Outpatient and Hybrid Cardiovascular Rehabilitation in Patients with Coronary Artery Disease)Original research articles

Marko Zváč, Ladislav Baťalík

Cor Vasa 2025, 67(3):336-343 | DOI: 10.33678/cor.2025.026  

Objective: To evaluate the effectiveness of traditional outpatient and hybrid cardiac rehabilitation (CR) programs in improving body composition and cardiovascular risk factors in patients with coronary artery disease (CAD). Methods: A total of 136 out of 169 CAD patients completed a 12-week CR program (outpatient: n = 91, hybrid: n = 45). Body composition was assessed using bioelectrical impedance analysis, while cardiovascular parameters were measured before and after the program. Results: Both groups showed significant improvements in body composition, cardiovascular parameters, and aerobic capacity (+18 W vs +19 W; p <0.05). The outpatient...

Prevalence of Near-Death Experiences (NDE) in Patients with Refractory Cardiac Arrest Treated with Conventional and Extracorporeal Cardiopulmonary ResuscitationOriginal research articles

Jaroslava Tereza Kovářová, Daniel Rob, František Trantina, Jan Bělohlávek

Cor Vasa 2025, 67(3):331-335 | DOI: 10.33678/cor.2025.031  

Objective: Near-death experiences (NDE) have not yet been studied in patients with refractory cardiac arrest treated with extracorporeal cardiopulmonary resuscitation (ECPR). The aim of this pilot project was to determine the prevalence of NDEs in patients from the randomized Prague OHCA study with refractory cardiac arrest and to analyze differences between patients resuscitated with standard cardiopulmonary resuscitation (CPR) and those resuscitated using the ECPR method. Methods: NDEs were analyzed using a standardized and internationally validated questionnaire among long-term survivors of the randomized Prague OHCA study. The prevalence of NDEs...

Enhancing TAVI Patient Evaluation: A User-Friendly Tool for CT-Derived Body Composition AssessmentOriginal research articles

Marek Kantor, Jakub Balušík, Piotr Branny, Lubomír Blaha, Jan Hečko, Matej Pekař

Cor Vasa 2025, 67(3):323-330 | DOI: 10.33678/cor.2025.008  

Background: CT-derived body composition analysis has emerged as a powerful prognostic tool for TAVI patient outcomes. However, widespread clinical implementation remains limited by complex software requirements and technical expertise barriers. This study aims to develop and validate an accessible web-based interface that streamlines the implementation of existing AutoMATiCA's validated CT-based body composition assessment in the pre-TAVI evaluation workflow. Methods: We developed a web-based interface integrating the validated AutoMATiCA's AI-driven segmentation software for automated body composition assessment. The system analyses pre-procedural...

Sto let od narození profesora Jiřího WidimskéhoPersonalities

Prof. MUDr. Jiří Widimský Jr., CSc.

Cor Vasa 2025, 67(2):307-309  

Filip Dosbaba, Ladislav Baťalík, Kateřina Filáková a kolektiv: Kardiovaskulární rehabilitace a prevenceBook reviews

Prof. MUDr. Jan Petrášek, DrSc.

Cor Vasa 2025, 67(2):316  

Profesor Josef Veselka oslaví šedesáté narozeninyPersonalia

Michael Aschermann

Cor Vasa 2025, 67(2):315  

Ludmila Klímová slaví životní jubileumPersonalia

Michael Aschermann

Cor Vasa 2025, 67(2):314  

Významné jubileum paní profesorky CífkovéPersonalia

Michael Aschermann

Cor Vasa 2025, 67(2):312-313  

Opustila nás prof. MUDr. Lenka Špinarová, Ph.D., FESC (6. 8. 1961-11. 4. 2025)Personalities

Prof. MUDr. Jiří Vítovec, CSc.; prof. MUDr. Jan Krejčí, Ph.D.

Cor Vasa 2025, 67(2):310-311  

Myocardial infarction in a young patient with antiphospholipid syndrome: A case reportCase reports

Marta Catarina Bernardo, Catarina Ribeiro Carvalho, Catarina Ferreira, Inês Silveira, Ana Batista, Sofia Silva Carvalho, Ilídio Moreira

Cor Vasa 2025, 67(2):302-304 | DOI: 10.33678/cor.2024.085  

This case report highlights the importance of a multimodal approach, tailored therapeutic interven- tions, and the poor prognosis of myocardial infarction with non-obstructive coronary arteries (MINOCA) in a young patient with antiphospholipid syndrome (APS). A 39-year-old man was admitted with a diagnosis of a ST elevation myocardial infarction (STEMI), in Killip class III. Angiography showed absence of obstructive epicardial coronary artery disease prompting further evaluation with cardiac magnetic resonance imaging (MRI). It revealed infarction scars in multiple arterial territories and severe left ventricular dysfunction. The patient evolved with...

(Current treatment options of pulmonary arterial hypertension in the Czech Republic, its limitations and perspectives, update of the therapeutic algorithm for pulmonary arterial hypertension. Expert consensus statement of the Working Group on Pulmonary Circulation of the Czech Society of Cardiology)Expert consensus statement

Pavel Jansa, David Ambrož, Marián Felšőci, Lucie Miksová, Jan Přeček, Hikmet Al-Hiti, Radek Pudil, Martin Hutyra

Cor Vasa 2025, 67(2):295-300 | DOI: 10.33678/cor.2025.046  

Pulmonary hypertension is defined as a syndrome characterized by an increase of the mean pulmonary artery pressure >20 mmHg. Pulmonary arterial hypertension (PAH) is a rare disease that accounts for approximately 1% of all cases of chronic pulmonary hypertension. In the pathophysiology, the key factor is initially vasoconstriction, followed by remodeling of pulmonary arterioles, accompanied by an increase of pulmonary vascular resistance and the right ventricle chronic pressure overload. In the treatment of PAH, medical therapy is dominant. Patients with a positive vasoreactivity testing are indicated for treatment with high doses of calcium channel...

2024 ESC Guidelines for the management of chronic coronary syndromes (Translation of the shortened document prepared by the Czech Interventional Cardiology Association of the Czech Society of Cardiology)Guidelines

Petr Kala, Radek Pudil, Ivo Varvařovský, Hana Skalická, Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, Banning AP, Budaj A, Buechel RR, Chiariello GA, Chieffo A, Christodorescu RM, Deaton C, Doenst T, Jones HW, Kunadian V, Mehilli J, Milojevic M, Piek JJ, Pugliese F, Rubboli A, Semb AG, Senior R, ten Berg JM, Van Belle E, Van Craenenbroeck EM, Vidal-Perez R, Winther S

Cor Vasa 2025, 67(2):230-294 | DOI: 10.33678/cor.2025.052  

2024 ESC Guidelines for the management of peripheral arterial and aortic diseases (Translation of the shortened document prepared by the Czech Society of Cardiology)Guidelines

Pavel Procházka, Petr Vařejka, Jiří Matuška, Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, Bura-Rivière A, De Backer J, Deglise S, Della Corte A, Heiss C, Kałużna-Oleksy M, Kurpas D, McEniery CM, Mirault T, Pasquet AA, Pitcher A, Schaubroeck HAI, Schlager O, Sirnes PA, Sprynger MG, Stabile E, Steinbach F, Thielmann M, van Kimmenade RRJ, Venermo M, Rodriguez-Palomares JF

Cor Vasa 2025, 67(2):182-229 | DOI: 10.33678/cor.2025.051  

2024 ESC Guidelines for the management of peripheral arterial and aortic diseases (Translation of the summary of the document prepared by the Czech Society of Angiology, 2025)Guidelines

Debora Karetová, Miroslav Chochola, Jana Hirmerová, Jiří Matuška, Jan Piťha, Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, Bura-Rivière A, De Backer J, Deglise S, Della Corte A, Heiss C, Kałużna-Oleksy M, Kurpas D, McEniery CM, Mirault T, Pasquet AA, Pitcher A, Schaubroeck HAI, Schlager O, Sirnes PA, Sprynger MG, Stabile E, Steinbach F, Thielmann M, van Kimmenade RRJ, Venermo M, Rodriguez-Palomares JF

Cor Vasa 2025, 67(2):135-181 | DOI: 10.33678/cor.2025.050  

2024 ESC Guidelines for the management of atrial fibrillation (Translation of the shortened document prepared by the Czech Heart Rhythm Association of the Czech Society of Cardiology)Guidelines

Lucie Šedivá, Robert Čihák, Štěpán Havránek, Martin Fiala, Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM, De Potter TJR, Dwight J, Guasti L, Hanke T, Jaarsma T, Lettino M, Løchen ML, Lumbers RT, Maesen B, Mølgaard I, Rosano GMC, Sanders P, Schnabel RB, Suwalski P, Svennberg E, Tamargo J, Tica O, Traykov V, Tzeis S, Kotecha D

Cor Vasa 2025, 67(2):95-134 | DOI: 10.33678/cor.2025.041  

Radek Ptáček, Petr Bartůněk (editoři): Bolest v medicíněKardio

Prof. MUDr. Jan Petrášek, DrSc.

Cor Vasa 2025, 67(1):88  

Zemřel prof. MUDr. Jiří Fodor, CSc., FRCPC, FAHA (28. 10. 1927–10. 12. 2024)Personalities

Prof. MUDr. Renata Cífková, CSc.

Cor Vasa 2025, 67(1):87  

Centra sportovní kardiologie: odborné stanoviskoKardio

Vladimír Tuka, Bogna Jiravská Godula, Otakar Jiravský, Peter Kubuš, Eliška Sovová

Cor Vasa 2025, 67(1):85-86  

Centra sportovní kardiologieKardio

Vladimír Tuka, Bogna Jiravská Godula, Otakar Jiravský,, Peter Kubuš, Eliška Sovová

Cor Vasa 2025, 67(1):83-84  

High-Sensitivity Cardiac Troponin T Elevation and Paroxysmal Supraventricular Tachycardia. Is it Always Acute Coronary Syndrome?Case reports

Serena Miccichè, Giuseppe Pelaggi, Maria Claudia Lo Nigro, Simone Celeste, Alice Moncada, Olga La Cognata, Armando Lo Savio, Salvatore Bonanno, Paolo Bellocchi, Graziella Agnelli, Alessio Currò

Cor Vasa 2025, 67(1):77-81 | DOI: 10.33678/cor.2024.063  

Background: Paroxysmal supraventricular tachycardia (PSVT) is a common arrhythmia often presenting with symptoms mimicking acute coronary syndrome (ACS). Case presentation: We present a case of a 58-year-old man with PSVT accompanied by chest pain and elevated high-sensitivity troponin (hs-Tn) levels. Coronary angiography revealed slow coronary flow in absence of obstructive disease. The patient's symptoms resolved spontaneously, and echocardiographic findings normalized upon discharge. Conclusions: This case underscores the diagnostic challenge of individuating ACS and highlights the transient troponin elevation seen in PSVT, potentially due to myocardial...