(Myocardium Remodelling: From Adaptation Mechanisms to Heart Failure Development)Review articles

Michal Laška, Marie Nováková, Tibor Stračina

Cor Vasa 2024, 66(1):53-64 | DOI: 10.33678/cor.2023.090  

Remodelling is one of the fundamental processes in the heart adaptation. It allows the heart to respond specifically to various stimuli and adapt to changed conditions. The basic remodelling processes involve hypertrophy and fibrosis. Remodelling is present at various levels and results in structural and subsequently functional changes in the myocardium. If the new state is compensated, it is referred to as physiological. Such remodelling includes so-called physiological hypertrophy induced by repeated sufficiently in- tense physical exertion. In pathological hypertrophy, the changes caused by remodelling are not sufficiently compensated. After adaptation...

How to invasively assess left ventricular function and its efficiency of workReview articles

Lukáš Povišer, Karol Čurila

Cor Vasa 2024, 66(1):44-51 | DOI: 10.33678/cor.2023.080  

Effective performance of the left ventricle requires the maintenance of a cardiac output as demanded by the systemic circulation without a high hemodynamic cost or pressure and without a high metabolic cost or oxygen demand by the left ventricular myocardium. In this article the left ventricle is considered as a pump and performance is based on evaluation of measurements of its pressure, volumes, and flow. Analysis of ventricular function in terms of pressure-volume relationships allows global and regional ventricular dynamics to be fully analyzed and relatively easily and precisely obtained with conductance catheter. The maximum rate of left ventricular...

Artificial intelligence in resting ECG: Higher accuracy in the interpretation of rhythm abnormalitiesOriginal research articles

Štěpán Havránek, Barbora Steklá, Michaela Veselá, Josef Holub, Michaela Zemková, Lucie Miksová, Karolína Kvasničková, Nikol Kubínová, Jean-Claude Lubanda, Milan Dusík, Josef Marek, Vladyslava Čeledová, Lenka Plačková

Cor Vasa 2024, 66(1):37-43 | DOI: 10.33678/cor.2023.096  

Objective: This study aimed to evaluate the performance of a developed novel AI-based ECG rhythm model (AI-ECGRM) in binary classification between sinus rhythm and arrhythmias. Methods: The interpretations generated by the AI-ECGRM were compared to the diagnostic conclusions made by cardiologists. The confusion matrix was used to verify the AI-ECGRM's sensitivity, specificity, positive predictive value, and negative predictive value. Results: The testing dataset included 1,491 randomly selected ECGs (mean age 65±21 years; 54% female). Out of the testing dataset, the highly advanced cardiologists diagnosed 1,271 ECGs as sinus rhythm and 220 as...

Clinical Outcomes of Isolated Non-Left Main Side Branch Ostial Stenosis: Medical Therapy versus Percutaneous Coronary Intervention (the ALP-SBO registry)Original research articles

Serkan Kahraman, Ahmet Guner, Fatih Uzun, Ali Kemal Kalkan, Mustafa Ali Yavas, Mehmet Cicek, Taner Sahin, Cemalettin Akman, Omer Celik, Mehmet Ertruk

Cor Vasa 2024, 66(1):29-36 | DOI: 10.33678/cor.2023.085  

Aim: Side branch (SB) ostial stenosis is a frequent bifurcation lesion and its optimal treatment strategy is still debated. Although the efficacy of the optimal medical therapy is well known, the comparison of the medical treatment and percutaneous coronary intervention (PCI) is controversial. Methods: A total of 357 consecutive patients with isolated SB ostial stenosis (Medina 0.0.1 classification) was evaluated retrospectively. Patients were divided into two groups; patients with only medical therapy (n = 305) and patients undergoing PCI (n = 52). Target vessel revascularization (TVR), myocardial infarction (MI), and mortality were evaluated as major...

Compliance of patients with atrial fibrillation using new oral anticoagulants - results surveyOriginal research articles

Petra Búřilová, Jiří Búřil, Michal Haršány, Kamila Dufková, Marta Šenkyříková, Dana Dolanová, Miloš Táborský, Andrea Pokorná

Cor Vasa 2024, 66(1):23-28 | DOI: 10.33678/cor.2023.095  

Introduction: Continuous medication use is essential for patients with atrial fibrillation using new oral anticoagulants. Older age and polymorbidity may affect compliance related to the anticoagulation therapy. Methods: An observational cohort study (STROBE) assessed patients' compliance with selected cardiovascular diagnoses and other comorbidities who received NOAC and outpatient care in specialized clinics in the Czech Republic in the questionnaire survey between April and May 2023. Results: Patients meeting the study criteria were approached by the treating physician for inclusion (4 cardiology and 1 neurology clinic). A total of 274 patients...

(Pulmonary embolism in the Tábor region - revised Geneva score and other predictors of PE on CT pulmonary angiogram)Original research articles

Jiří Adámek, Jan Kuchař

Cor Vasa 2024, 66(1):17-21 | DOI: 10.33678/cor.2023.098  

Aim: Analysis of the data of patients investigated in the Tabor Hospital for suspected pulmonary embolism with CT pulmonary angiogram (CTPA) in one year from March 2019 until February 2020. Evaluation of the usefulness of the Revised Geneva Score (RGS) in this group. Methods: Retrospective analysis of the data of all patients who underwent CTPA for suspected pulmonary embolism in the Department of Radiology in Tábor Hospital from March 2019 until February 2020. RGS value was calculated and compared with known CTPA results. Other clinical and laboratory parameters and their usefulness in prediction of pulmonary embolism diagnosis on CTPA were evaluated....

(Peripheral artery disease of the legs - the current state)Original research articles

Jiří Spáčil, Jaroslava Svobodová

Cor Vasa 2024, 66(1):12-16 | DOI: 10.33678/cor.2023.075  

Objective: Coronary artery disease changes over time. It is unknown how the peripheral artery disease of the legs has changed. Methods, the group: We used the medical records of our office to select patients with peripheral artery disease of the legs. The patients underwent clinical assessments including duplex sonography, and their blood pressure at the ankle was measured and expressed as ABI index. Further development of the clinical condition was then followed at subsequent visits. Worsening was defined as worsening of intermittent claudication and/or development of critical limb ischemia. We compared our findings to the results of previous as well...

(Use of multimodal imaging in patients with multiple ventricular extrasystoles - pilot results)Original research articles

Veronika Bednárová, Vladimír Kincl, Martin Pešl, Roman Panovský, Zdeněk Stárek, Věra Feitová, Jan Krejčí

Cor Vasa 2024, 66(1):6-11 | DOI: 10.33678/cor.2023.097  

Disturbances of autonomic function in the heart associated with premature ventricular complexes (PVC) are associated with a decrease in ejection fraction as well as increased cardiac morbidity and mortality. Standard imaging techniques such as cMRI and coronary angiography secure the exclusion of other causes of PVC as ischemia and progressive fibrosis. These methods are not suitable for cardiac autonomic nervous system imaging and can't describe the cause of related PVCs. This may be described by ¹²³I-metaiodobenzylguanidine (MIBG) scintigraphy. We examined a pilot group of 6 patients, in which 3 individuals presented a disorder in the...

Relationship between Functional Capacity and Medication Adherence in Heart FailureOriginal research articles

Libor Jelínek, Martin Modrák, Zdeněk Ramík, Lukáš Štos, Luděk Pavlů, Jan Václavík, Eliška Sovová

Cor Vasa 2023, 65(Suppl. 3):37-43 | DOI: 10.33678/cor.2023.064  

Introduction: This study investigated the relationship between the subjective New York Heart Association (NYHA) class and objective exercise capacity (VO_2peak) in patients with heart failure and whether it is influenced by medication adherence. Methods: Data from 170 heart failure patients in the Level-CHF register were analysed, and adherence was assessed by serum drug level testing. Objective exercise capacity was assessed by cardiopulmonary exercise testing using a bicycle ergometer. Results: Objective VO_2peak frequently exceeded the subjective NYHA class with 46% concordance, especially at the extreme ends of the spectrum....

Pulmonary edema in swimmers and diversReview articles

Radek Pudil

Cor Vasa 2023, 65(Suppl. 3):34-36 | DOI: 10.33678/cor.2023.076  

Pulmonary edema in swimmers and divers is defined as sudden onset of shortness of breath accompanied by cough, hemoptysis, and hypoxemia that occurs in association with increased physical activity, especially in a water/cold environment. It occurs more often in women and in the elderly, predisposing factors include a cold environment and the presence of some latent cardiovascular diseases. It is a potentially life-threaten- ing condition for athletes. Its therapy does not differ from the treatment of pulmonary cardiac edema. Early identification of persons with a higher risk and elimination of all potentially risk factors for its occurrence is very...

(Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. Translation of the document prepared by the Czech Society of Cardiology)Expert consensus statement

Vladimír Tuka, Eliška Sovová, Radek Pudil, Hana Skalická

Cor Vasa 2023, 65(Suppl. 3):5-33 | DOI: 10.33678/cor.2023.060  

Secondary prevention through comprehensive cardiac rehabilitation has been recognized as the most cost-effective intervention to ensure favourable outcomes across a wide spectrum of cardiovascular disease, reducing cardiovascular mortality, morbidity and disability, and to increase quality of life. The delivery of a comprehensive and 'modern' cardiac rehabilitation programme is mandatory both in the residential and the out-patient setting to ensure expected outcomes. The present position paper aims to update the practical recommendations on the core components and goals of cardiac rehabilitation intervention in different cardiovascular conditions,...

Jiří Vítovec, Peter Kollár, Karel Lábr: Betablokátory v léčbě kardiovaskulárních onemocněníBook reviews

Prof. MUDr. Michael Aschermann, DrSc.

Cor Vasa 2023, 65(Suppl. 1):76  

(Antithrombotic therapy in older patients)Editorial

Petr Ošťádal, Miloš Táborský, Zuzana Moťovská

Cor Vasa 2023, 65(Suppl. 1):6 | DOI: 10.33678/cor.2023.037  

(2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation. Translation of the document prepared by the Czech Society of Cardiology)Expert consensus statement

Miloš Táborský, Josef Kautzner, Marián Fedorco, Karol Čurila, Hanka Wünschová, Jan Pyszko, Miroslav Novák, Milan Kozák, Martin Válek, Rostislav Polášek, Patrik Keprt, Milena Kubíčková, Jiří Plášek, Vít Gloger, Alan Bulava, Vlastimil Vančura, Tomáš Skála, Petr Pařízek, Josef Daněk

Cor Vasa 2023, 65(Suppl. 1):23-75 | DOI: 10.33678/cor.2023.024

(Acute, periprocedural and longterm antithrombotic therapy in older adults: 2022 Update by the ESC Working Group on Thrombosis. Translation of the document prepared by the Czech Society of Cardiology)Expert consensus statement

Miloš Táborský, Zuzana Moťovská, Petr Ošťádal

Cor Vasa 2023, 65(Suppl. 1):7-22 | DOI: 10.33678/cor.2023.012

The fi rst international guidance on antithrombotic therapy in the elderly came from the European Society of Cardiology Working Group on Thrombosis in 2015. This same group has updated its previous report on antiplatelet and anticoagulant drugs for older patients with acute or chronic coronary syndromes, atrial fi brillation, or undergoing surgery or procedures typical of the elderly (transcatheter aortic valve implantationand left atrial appendage closure). The aim is to provide a succinct but comprehensive tool for readers to understand the bases of antithrombotic therapy in older patients, despite the complexities of comorbidities, comedications...

Opustil nás pan profesor MUDr. Bohumil Hučín, DrSc.Personalities

Michael Aschermann

Cor Vasa 2023, 65(6):893-894  

Zemřel profesor MUDr. Bohumil Hučín, DrSc.Personalities

Prof. MUDr. Tomáš Tláskal, CSc.

Cor Vasa 2023, 65(6):893-894  

21. konference České asociace akutní kardiologie - AbstraktaAbstracts

redakce

Cor Vasa 2023, 65(6):897-908  

Petr Bartůněk: Eponyma v medicíně aneb po kom to slovo jeBook reviews

Prof. MUDr. Jan Petrášek, DrSc.

Cor Vasa 2023, 65(6):896  

Profesorka MUDr. Zuzana Moťovská, Ph.D., získala cenu vlády ČR – Česká hlavaCurrent news

Michael Aschermann

Cor Vasa 2023, 65(6):895  

Profesor MUDr. Vladimír Staněk, CSc., FESC, získal státní vyznamenáníCurrent news

Michael Aschermann

Cor Vasa 2023, 65(6):895  

(European Health Data Space (EHDS) in the context of the digital transformation of cardiology and systemic changes of the health system in the Czech Republic)Expert consensus statement

Miloš Táborský, Lenka Kaška, Jiří Horecký, Jiří Batěk, Michal Vrablík, Aleš Linhart, Petr Ošťádal

Cor Vasa 2023, 65(6):880-891 | DOI: 10.33678/cor.2023.088  

Coronary evagination after self-apposing stent deployment: a rare but possible event. A clinical case at 4-year follow-upCase reports

Giuseppe Venuti, Francesca Consolo, Claudia Morabito, Alice Moncada, Olga La Cognata, Rosalba De Sarro, Alessandro Di Carlo, Armando Lo Savio, Marco Cerrito

Cor Vasa 2023, 65(6):877-879 | DOI: 10.33678/cor.2023.021  

Background: Coronary evagination is a coronary abnormality that has been associated with poor long-term outcomes irrespective of the presence of concomitant coronary artery disease (CAD). Its pathogenesis is still not well understood; intracoronary manipulation and percutaneous coronary intervention (PCI) are considered predictors of coronary enlargement through mechanism such as prolonged inflammation, suboptimal endothelialization and vessel positive remodeling. Some stent platforms, like self-apposing stents, seem to be more involved, causing more vessel remodeling. Case presentation: We report the case of a 79-year-old woman who underwent percutaneous...

Aspirin-induced Anaphylactoid Reactions in a Patient with Acute Coronary Syndrome Complicating Acute Lung Edema: a Case ReportCase reports

Meity Ardiana, Kevin Francio, Inna Maya Sufiyah, Fita Triastuti, Muhammad Nuh Hamdani

Cor Vasa 2023, 65(6):874-876 | DOI: 10.33678/cor.2023.028  

Background: Antiplatelet therapy is an essential treatment for patients with acute coronary syndrome. But a history of aspirin hypersensitivity has been reported and it might be challenging to treat a patient with this case. Case: A 65-year-old Javanese woman came to the emergency department and presented with dyspnea for three days and with orthopnea. Based on physical and supporting examination, the patient was diagnosed with ADHF. However, on the 3rd day of treatment, ECG showed new T wave inversion at lead V₁ to V₆, I, and aVL lead to NSTEACS. Loading doses of antiplatelets (clopidogrel and aspirin) were administered. Three...

An Experimental Case-Based Role Model Study of Mitral NeoChord Implantation with New Tools via Transapical ApproachCase reports

Ersin Doganozu, Ayşe Ceren Doganozu, Deniz Sarp Beyazpinar, Atilla Sezgin, Ibrahim Haldun Muderrisoglu, Alp Aydinalp

Cor Vasa 2023, 65(6):870-873 | DOI: 10.33678/cor.2023.044  

Increasing fragility with the aging population compels less invasive procedures. Even if cardiac surgeries are getting minimally invasive with new techniques and technological development in the field, many valve surgery candidates suffer from being qualified as inoperable due to fragility, unstable circulatory system, and to be post-myocardial infarction and their life is in danger every day that they are not operated. The main purpose of this case-based role model study is to invent a new technique for implanting a transapical mitral valve NeoChord implantation with new tools.

Surgical treatment of large aortic pseudoaneurysm in a 17-year-old patient: a case reportCase reports

Fadi Sabateen, Matej Nosáľ, Vladimír Soják, Aref Seif Nagi, Pavel Valentík, Michal Šagát

Cor Vasa 2023, 65(6):866-869 | DOI: 10.33678/cor.2023.049  

Aortic pseudoaneurysms are rare, but life-threatening conditions, that occur most commonly after previous cardiac surgery. The causes could be multifactorial such as chest trauma or infection. Clinical presentation can vary from asymptomatic to catastrophic outcomes. We report the successful surgical repair of a large ascending aortic pseudoaneurysm in an asymptomatic 17-year-old patient who had undergone aortic valve replacement 10 months ago.

Surgical treatment of aortic pseudoaneurysm after endovascular repairCase reports

Sandra Rečičárová, Michael Jonák

Cor Vasa 2023, 65(6):862-864 | DOI: 10.33678/cor.2023.062  

Thoracic aortic false aneurysm (TAFA) is a rare complication after cardiac surgery or after procedures on the thoracic aorta. We present a case report of a patient after Bentall's procedure for aortic dissection who developed an aortic pseudoaneurysm in distal anastomosis one year after surgery. Endovascular repair with occluder implantation was successfully performed. Three years later another false aneurysm from the left coronary artery occurred which had to be resected in open surgery.

Role of Corin in Cardiovascular DiseaseReview articles

Lutfu Askin, Fatih Poyraz

Cor Vasa 2023, 65(6):856-861 | DOI: 10.33678/cor.2023.055  

Corin, a type II transmembrane serine protease present in significant amounts in the heart, activates natri-uretic peptides. Corin enters the circulation from myocytes. Hypertension, heart failure, myocardial infarction, preeclampsia, and stroke are linked to circulating soluble corin. Our results suggest that circulating soluble corin may be a sensitive and specific cardiovascular disease (CVD) risk and predictive biomarker. Unfortunately, circulating soluble corin is difficult to use clinically. This review summarizes recent corin and CVD studies and suggests future corin research to improve risk prediction, prognosis, and medical treatment of CVDs...

(The effect of an inter-atrial communication in the treatment of the patients with heart failure with mildly reduced and preserved ejection fraction - current state of knowledge)Review articles

Filip Málek, Martin Mates, Tomáš Mráz, Vivek Reddy, Andreas Krüger, Petr Neužil

Cor Vasa 2023, 65(6):849-854 | DOI: 10.33678/cor.2023.068  

An elevated left atrial pressure at rest and especially at stress is the main cause of symptoms and an increased risk of hospitalization and death in patients with heart failure. The mechanistic approach with implantation of inter-atrial shunt device (IASD) to reduce left atrial pressure in the patients with heart failure with mildly reduced and preserved ejection fraction was feasible and safe in a pilot study. In a non-randomized REDUCE LAP-HF and a randomized REDUCE LAP-HF I study the implantation of IASD was associated with improved symptoms and hemodynamic parameters. The effect of IASD on the risk of cardiovascular events including death and...

DNA methylation and coronary artery disease: Brief summary of the main findingsReview articles

Asma Amrani-Midoun, Nadia Laredj, Farouk Boukerche

Cor Vasa 2023, 65(6):843-847 | DOI: 10.33678/cor.2023.067  

Cardiovascular disease (CVD) and more specifically coronary artery disease (CAD) continue to be the leading cause of mortality worldwide. Many genetic factors have been identified to contribute to the risk of develop-ing CAD. However, the etiology and pathophysiology of complex diseases such as CAD are driven not only by genetic factors but also by the interaction between genetic and environmental factors. Therefore, research-ers are now exploring the epigenome, a biological interface at which genetics and the environment can interact. DNA methylation is the main epigenetic form of gene regulation, and it is increasingly recognized to play an important...