Doporučený postup Evropské kardiologické společnosti pro léčbu kardiovaskulárních onemocnění u pacientů s diabetem 2023.Guidelines

Marx N, Federici M, Schütt K, Müller-Wieland D, Ajjan RA, Antunes MJ, Christodorescu RM, Crawford C, Di Angelantonio E, Eliasson B, Espinola-Klein C, Fauchier L, Halle M, Herrington WG, Kautzky-Willer A, Lambrinou E, Lesiak M, Lettino M, McGuire DK, Mullens W, Rocca B, Sattar N, Marx N, Federici M, Schütt K, Müller-Wieland D, Ajjan RA, Antunes MJ, Christodorescu RM, Crawford C, Di Angelantonio E, Eliasson B, Espinola-Klein C, Fauchier L, Halle M, Herrington WG, Kautzky-Willer A, Lambrinou E, Lesiak M, Lettino M, McGuire DK, Mullens W, Rocca B, Sattar N, Michal Vrablík, Hana Rosolová, Miloš Táborský

Cor Vasa 2024, 66(2):233-279 | DOI: 10.33678/cor.2024.031  

Doporučení ESC pro léčbu akutních koronárních syndromů 2023.Guidelines

Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, Claeys MJ, Dan GA, Dweck MR, Galbraith M, Gilard M, Hinterbuchner L, Jankowska EA, Jüni P, Kimura T, Kunadian V, Leosdottir M, Lorusso R, Pedretti RFE, Rigopoulos AG, Rubini Gimenez M, Thiele H, Vranckx P, Wassmann S, Wenger NK, Ibanez B, Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, Claeys MJ, Dan GA, Dweck MR, Galbraith M, Gilard M, Hinterbuchner L, Jankowska EA, Jüni P, Kimura T, Kunadian V, Leosdottir M, Lorusso R, Pedretti RFE, Rigopoulos AG, Rubini Gimenez M, Thiele H, Vranckx P, Wassmann S, Wenger NK, Ibanez B, Petr Kala, Petr Ošťádal, Zuzana Moťovská, Martin Mates, Dagmar Vondráková, Jan Bělohlávek, Petr Fila, Ivo Varvařovský

Cor Vasa 2024, 66(2):169-232 | DOI: 10.33678/cor.2024.029  

Doporučený postup Evropské kardiologické společnosti pro léčbu endokarditidy 2023.Guidelines

Delgado V, Ajmone Marsan N, de Waha S, Bonaros N, Brida M, Burri H, Caselli S, Doenst T, Ederhy S, Erba PA, Foldager D, Fosbøl EL, Kovac J, Mestres CA, Miller OI, Miro JM, Pazdernik M, Pizzi MN, Quintana E, Rasmussen TB, Ristić AD, Rodés-Cabau J, Sionis A, Zühlke LJ, Borger MA, Delgado V, Ajmone Marsan N, de Waha S, Bonaros N, Brida M, Burri H, Caselli S, Doenst T, Ederhy S, Erba PA, Foldager D, Fosbøl EL, Kovac J, Mestres CA, Miller OI, Miro JM, Pazdernik M, Pizzi MN, Quintana E, Rasmussen TB, Ristić AD, Rodés-Cabau J, Sionis A, Zühlke LJ, Borger MA, Hana Línková, Dan Marek, Martin Mates, Jiří Beneš, Aleš Mokráček, Jana Rubáčková Popelová, Jan Janoušek, Tomáš Paleček, Michal Pazderník, Tomáš Zatočil

Cor Vasa 2024, 66(2):112-168 | DOI: 10.33678/cor.2024.017  

(Focused on heart failure treatment according to the updated 2023 guidelines)Review articles

Jaroslav Brotánek

Cor Vasa 2024, 66(2):105-111 | DOI: 10.33678/cor.2024.025  

Acute and chronic heart failure remains a very serious and high priority problem in contemporary cardiology. New, modern drugs are currently emerging in the treatment of heart failure while the possibilities of their further use for this diagnosis are being expanded. These findings have been summarized in the 2023 update of the European Society of Cardiology Guidelines for heart failure. This article provides a brief summary of the new developments in pharmacotherapy based on the above recommendations.

(Fixed combination and adherence in patients with recent myocardial infarction or manifest cardiovascular disease - our experience from the SECURE trial)Original research articles

Jean-Claude Lubanda, Hana Lubanda

Cor Vasa 2024, 66(2):99-102 | DOI: 10.33678/cor.2024.022  

A lack of adherence is associated with a worse prognosis. Decreasing adherence in post-MI patients leads to an increased risk of recurrence of ischemic events. In addition, due to the aging population and improved quality care for ACS with better survival, there is an increase in the number of patients who need more personalized secondary preventive interventions. For these patients, improving adherence is another way to improve their prognosis. The latest research shows that combination therapy, preferably in a fixed combination, should improve patient adherence and reduce the risk of CV disease complications. Thanks to the reduction in the number...

Petra Hátlová, Roman Šmucler a Štěpán Svačina: Debaty bez cenzury 3Book reviews

Prof. MUDr. Jan Petrášek, DrSc.

Cor Vasa 2024, 66(1):91 | DOI: 10.33678/cor.2024.007  

Martin Polák: Urgentní příjem. Nejčastější znaky, příznaky a nemoci na oddělení urgentního příjmu. 3., přepracované a doplněné vydáníBook reviews

Prof. MUDr. Jan Petrášek, DrSc.

Cor Vasa 2024, 66(1):92 | DOI: 10.33678/cor.2024.013  

Za prof. MUDr. Ivanem Vaňkem, DrSc. (26. 6. 1942–8. 12. 2023)Personalities

Prof. MUDr. Josef Veselka, CSc.

Cor Vasa 2024, 66(1):90 | DOI: 10.33678/cor.2024.010  

Zemřel pan profesor MUDr. Ivan Vaněk, DrSc.Personalities

prof. MUDr. Jaroslav Lindner, CSc., FICS

Cor Vasa 2024, 66(1):89 | DOI: 10.33678/cor.2024.006  

(Commentary to the article The year in cardiovascular medicine 2022: the top 10 papers in heart failure and cardiomyopathies)Commentary

Filip Málek

Cor Vasa 2024, 66(1):87 | DOI: 10.33678/cor.2023.040  

Non-conducted premature atrial complexes: a silent culprit of atrial fibrillation onsetCase reports

Armando Lo Savio, Giampaolo Vetta, Antonio Parlavecchio, Rodolfo Caminiti, Michele Magnocavallo, Lorenzo Pistelli, Olga Mariarita La Cognata, Domenico Giovanni Della Rocca, Gianluca Di Bella, Pasquale Crea

Cor Vasa 2024, 66(1):84-86 | DOI: 10.33678/cor.2024.001  

Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults with substantial morbidity and mortality. AF increases the risk of stroke 5-fold compared to the general population and oral anticoagulant therapy represents the cornerstone for stroke prevention. Therefore, it is necessary to identify predictive factors for the onset of AF in order to screen patients with a high probability of AF development. We report the case of a 69-year-old patient asymptomatic for palpitation with a 24-hour Holter ECG showing several ncPACs (non-conducted premature atrial complexes) leading to AF onset.

Differentiating between Exercise-Induced ST-Segment Abnormalities Secondary to Wolff-Parkinson-White (WPW) Syndrome and Acute Myocardial InfarctionCase reports

Meity Ardiana, Putu Dwipa Krisna Devi, Ryan Enast Intan, Inna Maya Sufiyah

Cor Vasa 2024, 66(1):80-83 | DOI: 10.33678/cor.2023.081  

Background: Exercise stress testing (EST) can cause false-positive diagnoses of myocardial infarction (MI) in individuals with Wolff-Parkinson-White (WPW) syndrome. Case: A 30-year-old male had a history of palpitation and near syncope 2 months before examination. The pre-test probability (PTP) score was 1% and baseline ECG showed typical features of WPW syndrome. Additionally, risk stratification was performed with EST using the Bruce protocol. Persistent ventricular preexcitation (VPE) with upsloping 3.0 mm ST-segment depression was found in precordial leads at the fourth stage, while the aVR lead showed a 3.0 mm ST-segment elevation. Conclusion:...

Post-infarction ventricular septal rupture; a case report: An insight to the AmericasCase reports

David Jacobo Sánchez Amaya, Nancy Gabriela Rodríguez Murillo, Daniel Sánchez Amaya, Haroldo López García

Cor Vasa 2024, 66(1):76-79 | DOI: 10.33678/cor.2023.065  

Ventricular septal rupture (VSR) constitutes one of the possible mechanical complications following an acute myocardial infarction (AMI), even though very infrequent, it bears an elevated high mortality rate. Although most patients develop florid clinical manifestations, a minority might have a silent evolution, experiencing a subacute heart failure (HF) onset or decompensation instead. Once identified, prompt treatment is mandatory. Management, consistent of medical therapy (i.e.; anti-ischemic and afterload reducing medications) along with definite repair, either through interventional or surgical technique, is necessary, since if uncor- rected,...

(Cardiac tumour presenting as fever of unknown origin)Case reports

Lenka Hartmanová, Juraj Hrečko, Monika Fialová, Karel Mědílek, Pavel Žáček, Václav Stejskal, Petr Pařízek

Cor Vasa 2024, 66(1):71-75 | DOI: 10.33678/cor.2023.073  

Cardiac myxoma is the most common primary tumour of the heart. We present a case of a 46-year-old man with a 3-month history of progressive fatigue, exertional dyspnoea, fever, and elevated inflammatory markers. Echocardiography revealed left atrial tumour. The patient underwent successful surgical resection of the tumour; the histological study of the mass confirmed the diagnosis of myxoma.

(The CD36 receptor - the link between inflammation, lipid metabolism, and cardiovascular disease)Review articles

Rudolf Poledne, Ivana Králová Lesná

Cor Vasa 2024, 66(1):66-70 | DOI: 10.33678/cor.2024.005  

The CD36/FAT (fatty acid translocator) receptor is a crucial player in cardiovascular diseases, featuring a consistent structure across species. Its expression in adipose tissue, skeletal muscle, liver, and arterial wall macrophages underscores its importance. Beyond scavenging oxidized LDL (oxLDL), CD36 accelerates the pro-inflammatory processes in all these organs. Specific microenvironments of adipose tissue with high concentrations of free long-chain fatty acids, insulin, and glucose induce polarization by tissue-specific path- ways producing metabolically activated pro-inflammatory macrophages (MAPIMs) with high CD36 expres- sion. The proportion...

(Myocardium Remodelling: From Adaptation Mechanisms to Heart Failure Development)Review articles

Michal Laška, Marie Nováková, Tibor Stračina

Cor Vasa 2024, 66(1):53-64 | DOI: 10.33678/cor.2023.090  

Remodelling is one of the fundamental processes in the heart adaptation. It allows the heart to respond specifically to various stimuli and adapt to changed conditions. The basic remodelling processes involve hypertrophy and fibrosis. Remodelling is present at various levels and results in structural and subsequently functional changes in the myocardium. If the new state is compensated, it is referred to as physiological. Such remodelling includes so-called physiological hypertrophy induced by repeated sufficiently in- tense physical exertion. In pathological hypertrophy, the changes caused by remodelling are not sufficiently compensated. After adaptation...

How to invasively assess left ventricular function and its efficiency of workReview articles

Lukáš Povišer, Karol Čurila

Cor Vasa 2024, 66(1):44-51 | DOI: 10.33678/cor.2023.080  

Effective performance of the left ventricle requires the maintenance of a cardiac output as demanded by the systemic circulation without a high hemodynamic cost or pressure and without a high metabolic cost or oxygen demand by the left ventricular myocardium. In this article the left ventricle is considered as a pump and performance is based on evaluation of measurements of its pressure, volumes, and flow. Analysis of ventricular function in terms of pressure-volume relationships allows global and regional ventricular dynamics to be fully analyzed and relatively easily and precisely obtained with conductance catheter. The maximum rate of left ventricular...

Artificial intelligence in resting ECG: Higher accuracy in the interpretation of rhythm abnormalitiesOriginal research articles

Štěpán Havránek, Barbora Steklá, Michaela Veselá, Josef Holub, Michaela Zemková, Lucie Miksová, Karolína Kvasničková, Nikol Kubínová, Jean-Claude Lubanda, Milan Dusík, Josef Marek, Vladyslava Čeledová, Lenka Plačková

Cor Vasa 2024, 66(1):37-43 | DOI: 10.33678/cor.2023.096  

Objective: This study aimed to evaluate the performance of a developed novel AI-based ECG rhythm model (AI-ECGRM) in binary classification between sinus rhythm and arrhythmias. Methods: The interpretations generated by the AI-ECGRM were compared to the diagnostic conclusions made by cardiologists. The confusion matrix was used to verify the AI-ECGRM's sensitivity, specificity, positive predictive value, and negative predictive value. Results: The testing dataset included 1,491 randomly selected ECGs (mean age 65±21 years; 54% female). Out of the testing dataset, the highly advanced cardiologists diagnosed 1,271 ECGs as sinus rhythm and 220 as...

Clinical Outcomes of Isolated Non-Left Main Side Branch Ostial Stenosis: Medical Therapy versus Percutaneous Coronary Intervention (the ALP-SBO registry)Original research articles

Serkan Kahraman, Ahmet Guner, Fatih Uzun, Ali Kemal Kalkan, Mustafa Ali Yavas, Mehmet Cicek, Taner Sahin, Cemalettin Akman, Omer Celik, Mehmet Ertruk

Cor Vasa 2024, 66(1):29-36 | DOI: 10.33678/cor.2023.085  

Aim: Side branch (SB) ostial stenosis is a frequent bifurcation lesion and its optimal treatment strategy is still debated. Although the efficacy of the optimal medical therapy is well known, the comparison of the medical treatment and percutaneous coronary intervention (PCI) is controversial. Methods: A total of 357 consecutive patients with isolated SB ostial stenosis (Medina 0.0.1 classification) was evaluated retrospectively. Patients were divided into two groups; patients with only medical therapy (n = 305) and patients undergoing PCI (n = 52). Target vessel revascularization (TVR), myocardial infarction (MI), and mortality were evaluated as major...

Compliance of patients with atrial fibrillation using new oral anticoagulants - results surveyOriginal research articles

Petra Búřilová, Jiří Búřil, Michal Haršány, Kamila Dufková, Marta Šenkyříková, Dana Dolanová, Miloš Táborský, Andrea Pokorná

Cor Vasa 2024, 66(1):23-28 | DOI: 10.33678/cor.2023.095  

Introduction: Continuous medication use is essential for patients with atrial fibrillation using new oral anticoagulants. Older age and polymorbidity may affect compliance related to the anticoagulation therapy. Methods: An observational cohort study (STROBE) assessed patients' compliance with selected cardiovascular diagnoses and other comorbidities who received NOAC and outpatient care in specialized clinics in the Czech Republic in the questionnaire survey between April and May 2023. Results: Patients meeting the study criteria were approached by the treating physician for inclusion (4 cardiology and 1 neurology clinic). A total of 274 patients...

(Pulmonary embolism in the Tábor region - revised Geneva score and other predictors of PE on CT pulmonary angiogram)Original research articles

Jiří Adámek, Jan Kuchař

Cor Vasa 2024, 66(1):17-21 | DOI: 10.33678/cor.2023.098  

Aim: Analysis of the data of patients investigated in the Tabor Hospital for suspected pulmonary embolism with CT pulmonary angiogram (CTPA) in one year from March 2019 until February 2020. Evaluation of the usefulness of the Revised Geneva Score (RGS) in this group. Methods: Retrospective analysis of the data of all patients who underwent CTPA for suspected pulmonary embolism in the Department of Radiology in Tábor Hospital from March 2019 until February 2020. RGS value was calculated and compared with known CTPA results. Other clinical and laboratory parameters and their usefulness in prediction of pulmonary embolism diagnosis on CTPA were evaluated....

(Peripheral artery disease of the legs - the current state)Original research articles

Jiří Spáčil, Jaroslava Svobodová

Cor Vasa 2024, 66(1):12-16 | DOI: 10.33678/cor.2023.075  

Objective: Coronary artery disease changes over time. It is unknown how the peripheral artery disease of the legs has changed. Methods, the group: We used the medical records of our office to select patients with peripheral artery disease of the legs. The patients underwent clinical assessments including duplex sonography, and their blood pressure at the ankle was measured and expressed as ABI index. Further development of the clinical condition was then followed at subsequent visits. Worsening was defined as worsening of intermittent claudication and/or development of critical limb ischemia. We compared our findings to the results of previous as well...

(Use of multimodal imaging in patients with multiple ventricular extrasystoles - pilot results)Original research articles

Veronika Bednárová, Vladimír Kincl, Martin Pešl, Roman Panovský, Zdeněk Stárek, Věra Feitová, Jan Krejčí

Cor Vasa 2024, 66(1):6-11 | DOI: 10.33678/cor.2023.097  

Disturbances of autonomic function in the heart associated with premature ventricular complexes (PVC) are associated with a decrease in ejection fraction as well as increased cardiac morbidity and mortality. Standard imaging techniques such as cMRI and coronary angiography secure the exclusion of other causes of PVC as ischemia and progressive fibrosis. These methods are not suitable for cardiac autonomic nervous system imaging and can't describe the cause of related PVCs. This may be described by ¹²³I-metaiodobenzylguanidine (MIBG) scintigraphy. We examined a pilot group of 6 patients, in which 3 individuals presented a disorder in the...

Relationship between Functional Capacity and Medication Adherence in Heart FailureOriginal research articles

Libor Jelínek, Martin Modrák, Zdeněk Ramík, Lukáš Štos, Luděk Pavlů, Jan Václavík, Eliška Sovová

Cor Vasa 2023, 65(Suppl. 3):37-43 | DOI: 10.33678/cor.2023.064  

Introduction: This study investigated the relationship between the subjective New York Heart Association (NYHA) class and objective exercise capacity (VO_2peak) in patients with heart failure and whether it is influenced by medication adherence. Methods: Data from 170 heart failure patients in the Level-CHF register were analysed, and adherence was assessed by serum drug level testing. Objective exercise capacity was assessed by cardiopulmonary exercise testing using a bicycle ergometer. Results: Objective VO_2peak frequently exceeded the subjective NYHA class with 46% concordance, especially at the extreme ends of the spectrum....

Pulmonary edema in swimmers and diversReview articles

Radek Pudil

Cor Vasa 2023, 65(Suppl. 3):34-36 | DOI: 10.33678/cor.2023.076  

Pulmonary edema in swimmers and divers is defined as sudden onset of shortness of breath accompanied by cough, hemoptysis, and hypoxemia that occurs in association with increased physical activity, especially in a water/cold environment. It occurs more often in women and in the elderly, predisposing factors include a cold environment and the presence of some latent cardiovascular diseases. It is a potentially life-threaten- ing condition for athletes. Its therapy does not differ from the treatment of pulmonary cardiac edema. Early identification of persons with a higher risk and elimination of all potentially risk factors for its occurrence is very...

(Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. Translation of the document prepared by the Czech Society of Cardiology)Expert consensus statement

Vladimír Tuka, Eliška Sovová, Radek Pudil, Hana Skalická

Cor Vasa 2023, 65(Suppl. 3):5-33 | DOI: 10.33678/cor.2023.060  

Secondary prevention through comprehensive cardiac rehabilitation has been recognized as the most cost-effective intervention to ensure favourable outcomes across a wide spectrum of cardiovascular disease, reducing cardiovascular mortality, morbidity and disability, and to increase quality of life. The delivery of a comprehensive and 'modern' cardiac rehabilitation programme is mandatory both in the residential and the out-patient setting to ensure expected outcomes. The present position paper aims to update the practical recommendations on the core components and goals of cardiac rehabilitation intervention in different cardiovascular conditions,...

Jiří Vítovec, Peter Kollár, Karel Lábr: Betablokátory v léčbě kardiovaskulárních onemocněníBook reviews

Prof. MUDr. Michael Aschermann, DrSc.

Cor Vasa 2023, 65(Suppl. 1):76  

(Antithrombotic therapy in older patients)Editorial

Petr Ošťádal, Miloš Táborský, Zuzana Moťovská

Cor Vasa 2023, 65(Suppl. 1):6 | DOI: 10.33678/cor.2023.037  

(2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation. Translation of the document prepared by the Czech Society of Cardiology)Expert consensus statement

Miloš Táborský, Josef Kautzner, Marián Fedorco, Karol Čurila, Hanka Wünschová, Jan Pyszko, Miroslav Novák, Milan Kozák, Martin Válek, Rostislav Polášek, Patrik Keprt, Milena Kubíčková, Jiří Plášek, Vít Gloger, Alan Bulava, Vlastimil Vančura, Tomáš Skála, Petr Pařízek, Josef Daněk

Cor Vasa 2023, 65(Suppl. 1):23-75 | DOI: 10.33678/cor.2023.024

(Acute, periprocedural and longterm antithrombotic therapy in older adults: 2022 Update by the ESC Working Group on Thrombosis. Translation of the document prepared by the Czech Society of Cardiology)Expert consensus statement

Miloš Táborský, Zuzana Moťovská, Petr Ošťádal

Cor Vasa 2023, 65(Suppl. 1):7-22 | DOI: 10.33678/cor.2023.012

The fi rst international guidance on antithrombotic therapy in the elderly came from the European Society of Cardiology Working Group on Thrombosis in 2015. This same group has updated its previous report on antiplatelet and anticoagulant drugs for older patients with acute or chronic coronary syndromes, atrial fi brillation, or undergoing surgery or procedures typical of the elderly (transcatheter aortic valve implantationand left atrial appendage closure). The aim is to provide a succinct but comprehensive tool for readers to understand the bases of antithrombotic therapy in older patients, despite the complexities of comorbidities, comedications...